免疫毒性剂对传染病免疫抵抗力有害影响的风险评估：以紫外线为例。
Risk assessment for the harmful effects of immunotoxic agents on the immunological resistance to infectious diseases: ultraviolet light as an example.
作者信息
Van Loveren H, Goettsch W, Slob W, Garssen J
机构信息
National Institute of Public Health and Environmental Protection, Bilthoven, The Netherlands.
出版信息
Toxicology. 1997 Apr 11;119(1):59-64. doi: 10.1016/s0300-483x(96)03597-4.
Risk assessment comprises four steps: hazard identification, dose-response assessment, exposure assessment and risk characterization. As an example we have assessed the risk of decreased host resistance to infections due to effects of the immunotoxic agent - ultraviolet light. We have analysed effects of UVB radiation on basal immune functions in rats and man, and the immunological resistance to infectious diseases in rats. Non-threshold mathematical methods were used in order to estimate the risk for the human population after increased exposure to UVB radiation. These data demonstrate that UVB radiation, at doses relevant to outdoors exposure, may affect the immunological resistance to infectious diseases in human individuals. This study may also provide a basis for a strategy to assess the risk of adverse effects of exposure to immunotoxic agents.
风险评估包括四个步骤
危害识别、剂量反应评估、暴露评估和风险特征描述。例如，我们评估了免疫毒性剂——紫外线对宿主抗感染抵抗力降低的风险。我们分析了紫外线B辐射对大鼠和人类基础免疫功能的影响，以及大鼠对传染病的免疫抵抗力。为了估计人群在增加紫外线B辐射暴露后的风险，我们使用了非阈值数学方法。这些数据表明，与户外暴露相关剂量的紫外线B辐射可能会影响人类个体对传染病的免疫抵抗力。这项研究也可能为评估暴露于免疫毒性剂的不良反应风险的策略提供依据。
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