D'Elios M M, Romagnani P, Scaletti C, Annunziato F, Manghetti M, Mavilia C, Parronchi P, Pupilli C, Pizzolo G, Maggi E, Del Prete G F, Romagnani S
Institute of Internal Medicine and Immunoallergology, Department of Physiopathology, University of Florence, Italy.
J Leukoc Biol. 1997 May;61(5):539-44.
CD30 is a member of the tumor necrosis factor (TNF) receptor family, originally described as a marker for Hodgkin and Reed-Sternberg cells in Hodgkin's disease, which has been found to be preferentially expressed by T cells producing Th2-type cytokines. The presence of CD30 expression was assessed by both immunohistochemistry and reverse transcriptase-polymerase chain reaction in the target organs of patients with Th1- or Th2-dominated disorders. CD30 expression was found in neither the gut of patients with Crohn's disease nor in the gastric antrum of Helicobacter pylori-infected patients, where there was high interferon-gamma (IFN-gamma) expression. In contrast, high CD30 expression in the apparent absence of IFN-gamma expression was observed in the skin of patients with systemic sclerosis or chronic graft versus host disease (GVHD), which can be considered Th2-dominated disorders. Moreover, high levels of soluble CD30 were found in the serum of both systemic sclerosis and GVHD patients but not in the serum of patients suffering from multiple sclerosis, a Th1-dominated disorder. Thus, CD30 expression appears to be preferentially associated with Th2-type responses not only in vitro but also in vivo.
CD30是肿瘤坏死因子（TNF）受体家族的成员，最初被描述为霍奇金病中霍奇金和里德-斯腾伯格细胞的标志物，现已发现它在产生Th2型细胞因子的T细胞中优先表达。通过免疫组织化学和逆转录聚合酶链反应评估了Th1或Th2主导疾病患者靶器官中CD30的表达情况。在克罗恩病患者的肠道以及幽门螺杆菌感染患者的胃窦中均未发现CD30表达，而这些部位存在高表达的干扰素-γ（IFN-γ）。相反，在系统性硬化症或慢性移植物抗宿主病（GVHD）患者的皮肤中观察到明显缺乏IFN-γ表达时却有高CD30表达，这两种疾病可被视为Th2主导的疾病。此外，在系统性硬化症和GVHD患者的血清中发现高水平的可溶性CD30，但在多发性硬化症（一种Th1主导的疾病）患者的血清中未发现。因此，CD30表达似乎不仅在体外而且在体内都优先与Th2型反应相关。
