Dipartimento di Medicina Sperimentale e Clinica, Università degli Studi di Firenze, Firenze, Italy.
Escuela de Salud del Chaco Tekove Katu, Gutierrez, Plurinational State of Bolivia.
Am J Trop Med Hyg. 2020 Apr;102(4):847-850. doi: 10.4269/ajtmh.19-0180.
In the Bolivian Chaco, recent surveys documented a dramatic decrease in the prevalence of soil-transmitted helminth (STH) infections as compared with the 1980s after thirty years of preventive chemotherapy (PC). Concomitant immunological rearrangements are expected. Because nematode infections are associated with increased levels of circulating IgE and glycoprotein CD30 soluble form (sCD30), this study aims to evaluate changes in serological markers of T helper (Th)2-cells activity between 1987 (high STH prevalence) and 2013 (low STH prevalence) in rural communities in the Bolivian Chaco area. We collected 151 sera during two different surveys in 1987 ( = 65) and 2013 ( = 86) and measured the concentration of total IgE and sCD30 by immunoassays. We found a statistically significant age-independent decrease in the total IgE ( < 0.0001) and sCD30 ( < 0.0001) from 1987 to 2013. The significant decrease in serological Th2 markers (IgE and sCD30) between 1987 and 2013 is consistent with the drop in STH prevalence in this geographical area during the same period of time. Further studies might elucidate the clinical and epidemiological impact of these serological rearrangements.
在玻利维亚查科地区，经过三十年的预防性化疗（PC）后，最近的调查记录显示，与 20 世纪 80 年代相比，土壤传播性蠕虫（STH）感染的流行率显著下降。预计会出现伴随的免疫重排。由于线虫感染与循环 IgE 和糖蛋白 CD30 可溶性形式（sCD30）水平升高有关，因此本研究旨在评估玻利维亚查科地区农村社区在 1987 年（高 STH 流行率）和 2013 年（低 STH 流行率）之间 Th2 细胞活性的血清学标志物的变化。我们在 1987 年（=65）和 2013 年（=86）的两次不同调查中收集了 151 份血清，并通过免疫测定测量了总 IgE 和 sCD30 的浓度。我们发现，从 1987 年到 2013 年，总 IgE（<0.0001）和 sCD30（<0.0001）呈统计学上的年龄独立下降。1987 年至 2013 年间血清 Th2 标志物（IgE 和 sCD30）的显著下降与同期该地理区域 STH 流行率的下降一致。进一步的研究可能阐明这些血清重排的临床和流行病学影响。
