Meybehm M, Fischer H P
Department of Pathology, University of Bonn, F.R.G.
Am J Dermatopathol. 1997 Apr;19(2):154-61. doi: 10.1097/00000372-199704000-00009.
We carried out an immunohistochemical analysis of nine spiradenomas and seven cylindromas. Our findings underscore the histomorphological similarities of the two adnexal neoplasms-namely, the expression of S-100 protein ascribed to eccrine differentiation within the tubular and large, pale-staining cells of both entities. Human milk fat globulin (HMFG) and lysozyme, two markers associated with apocrine differentiation, are expressed by tubular cells in spiradenomas and cylindromas. Lysozyme is also expressed in cylindromas by large, pale-staining cells. In addition, antibodies to alpha-smooth muscle actin strongly characterized the small basaloid cells of both types of neoplasm. Both spiradenomas and cylindromas expressed identical cytokeratin patterns. As with the various regions of eccrine and apocrine units, the expression by spiradenomas and cylindromas of keratins 7, 8, and 18 indicates differentiation toward the secretory tissue, whereas the expression of keratin 14 in some of the neoplastic cells points toward ductal differentiation. Malformed ductal and glandular structures in continuity with evolving spiradenomas and cylindromas in two of our cases also suggest that these tumors might arise from abortive adenxal anlagen.
我们对9例汗腺螺旋瘤和7例圆柱瘤进行了免疫组织化学分析。我们的研究结果强调了这两种附属器肿瘤在组织形态学上的相似性，即在这两种肿瘤的管状及大的淡染细胞中均有归因于小汗腺分化的S-100蛋白表达。人乳脂肪球蛋白（HMFG）和溶菌酶这两种与顶泌汗腺分化相关的标志物，在汗腺螺旋瘤和圆柱瘤的管状细胞中均有表达。溶菌酶在圆柱瘤的大的淡染细胞中也有表达。此外，α-平滑肌肌动蛋白抗体能很好地表征这两种肿瘤的小基底样细胞。汗腺螺旋瘤和圆柱瘤均表达相同的细胞角蛋白模式。与小汗腺和顶泌汗腺单位的不同区域一样，汗腺螺旋瘤和圆柱瘤对角蛋白7、8和18的表达表明其向分泌组织分化，而部分肿瘤细胞中角蛋白14的表达则提示导管分化。在我们的2例病例中，与不断发展的汗腺螺旋瘤和圆柱瘤相连的畸形导管和腺结构也提示这些肿瘤可能起源于发育不全的附属器原基。
