Kumari K T, Ravikumar A, Kurup P A
Department of Biochemistry, University of Kerala, Trivandrum.
Indian Heart J. 1997 Jan-Feb;49(1):49-51.
Nutritional factors, mainly low protein intakes have been implicated in the pathogenesis of endomyocardial fibrosis (EMF), the incidence of which is high in Kerala. As there is only marginal protein deficiency in the Kerala population, this may not be a causative factor. Studies have revealed low levels of magnesium (Mg) in the serum of these patients and high concentration of glycosaminoglycans. Accumulation of glycosaminoglycan-associated Mg deficiency is observed in the serum of EMF patients. The heart tissue from autopsy samples of EMF patients also showed accumulation of glycosaminoglycans.
营养因素，主要是蛋白质摄入不足，被认为与心内膜心肌纤维化（EMF）的发病机制有关，该病在喀拉拉邦的发病率很高。由于喀拉拉邦人群仅有轻微的蛋白质缺乏，这可能不是致病因素。研究显示这些患者血清中的镁（Mg）水平较低，而糖胺聚糖浓度较高。在EMF患者的血清中观察到与糖胺聚糖相关的镁缺乏的积累。EMF患者尸检样本的心脏组织也显示出糖胺聚糖的积累。
