Cardoe N, de-Silva M, Glass R C, Risdall P C
Curr Med Res Opin. 1977;5(1):21-5. doi: 10.1185/03007997709108971.
Serum concentrations of flurbiprofen were measured following single oral doses of 50 mg to 200 mg in patients who previously had received flurbiprofen over long periods of time. The apparent elimination half-lives in groups of patients who received different doses were not significantly different from each other nor from the value previously obtained in a group of healthy volunteers given a single oral dose of 50 mg. Areas under serum concentration versus time curves were linearly related to dose over the range of doses examined. The results indicate that the pharmacokinetics of flurbiprofen are not significantly dose-dependent over the range of doses studied and that administration of relatively high doses of flurbiprofen over long periods of time neither induces nor inhibits flurbiprofen metabolism.
在长期服用氟比洛芬的患者中，单次口服50毫克至200毫克剂量后测量血清氟比洛芬浓度。接受不同剂量的患者组的表观消除半衰期彼此之间无显著差异，也与先前给予单次口服50毫克剂量的一组健康志愿者所获得的值无显著差异。在所研究的剂量范围内，血清浓度-时间曲线下面积与剂量呈线性相关。结果表明，在所研究的剂量范围内，氟比洛芬的药代动力学无显著剂量依赖性，并且长期给予相对高剂量的氟比洛芬既不诱导也不抑制氟比洛芬代谢。
