Chalmers T M, Glass R C, Risdall P C
Curr Med Res Opin. 1977;5(1):17-20. doi: 10.1185/03007997709108970.
In 3 patients with active rheumatoid disease, concentrations of flurbiprofen of approximately 2 microgram per ml were achieved in synovial fluid 3 hours after a single oral dose of flurbiprofen (100 mg). The highest concentrations were seen between 3 and 9 hours after administration of the dose. The concentration of flurbiprofen in synovial fluid seemed to fall more slowly than in the circulation, but more extensive data would be needed to confirm this. In all 3 patients the drug was absorbed rapidly into the circulation, the highest serum concentrations of 7 microgram to 9 microgram per ml being seen in the first blood sample withdrawn 1.5 hours after administration of the dose. Serum concentrations fell with a mean apparent half-life of approximately 3 hours.
在3例活动性类风湿病患者中，单次口服氟比洛芬（100毫克）3小时后，滑液中氟比洛芬浓度达到约每毫升2微克。给药后3至9小时出现最高浓度。滑液中氟比洛芬浓度下降似乎比循环中更慢，但需要更多数据来证实这一点。在所有3例患者中，药物迅速吸收入循环，给药后1.5小时采集的第一份血样中血清最高浓度为每毫升7微克至9微克。血清浓度下降，平均表观半衰期约为3小时。
