Lunshof S, Boer K, van Hoffen G, Wolf H, Mirmiran M
University of Amsterdam, Department of Obstetrics and Gynaecology, The Netherlands.
Early Hum Dev. 1997 Apr 25;48(1-2):47-57. doi: 10.1016/s0378-3782(96)01802-6.
In a discordant anencephalic twin the hypothesis was tested that the fetal brain is necessary for the expression of a diurnal rhythm in fetal heart rate. Fetal heart rate recordings were made over a 24 h period in a discordant anencephalic twin pregnancy and in three normal twin pregnancies. Cosinor analysis was used to assess rhythmicity in fetal heart rate and maternal heart rate or activity. Correlations between maternal and fetal rhythms were calculated. A significant diurnal rhythm was found for the fetuses of the control twins, but in neither of the fetuses of the discordant anencephalic twin pregnancy. The maternal rhythm was 1-2 h in advance of the heart rate rhythms in all fetuses except the anencephalic one, whose heart rate did not show any correlation with the maternal diurnal rhythm. We conclude that the fetal brain contributes to the generation of the diurnal rhythm in fetal heart rate and synchronization of maternal-fetal rhythms.
在一对不一致的无脑儿双胎中，对胎儿大脑是否是胎儿心率昼夜节律表达所必需的这一假说进行了检验。在一例不一致的无脑儿双胎妊娠以及三例正常双胎妊娠中，对胎儿心率进行了24小时的记录。采用余弦分析来评估胎儿心率以及母亲心率或活动的节律性。计算了母亲和胎儿节律之间的相关性。在对照双胎的胎儿中发现了显著的昼夜节律，但在不一致的无脑儿双胎妊娠的任何一个胎儿中均未发现。除无脑儿外，所有胎儿的母亲节律均比心率节律提前1 - 2小时，无脑儿的心率与母亲昼夜节律无任何相关性。我们得出结论，胎儿大脑有助于胎儿心率昼夜节律的产生以及母胎节律的同步。
