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双正态ROC曲线稳健性的局限性:模型误设及决策阈值位置对偏差、精度、规模和效能的影响

Limitations to the robustness of binormal ROC curves: effects of model misspecification and location of decision thresholds on bias, precision, size and power.

作者信息

Walsh S J

机构信息

Department of Community Medicine, School of Medicine, University of Connecticut Health Center, Farmington 06030-1910, USA.

出版信息

Stat Med. 1997 Mar 30;16(6):669-79. doi: 10.1002/(sici)1097-0258(19970330)16:6<669::aid-sim489>3.0.co;2-q.

Abstract

This paper concerns robustness of the binormal assumption for inferences that pertain to the area under an ROC curve. I applied the binormal model to rating method data sets sampled from bilogistic curves and observed small biases in area estimates. Bias increased as the range of decision thresholds decreased. The variance of area estimates also increased as the range of decision thresholds decreased. Together, minor bias and inflated variance substantially altered the size and power of statistical tests that compared areas under bilogistic ROC curves. I repeated the simulations by applying the binormal assumption to data sampled from binormal curves. Biases in area estimates were minimal for the binormal data, but the variance of area estimates was again higher when the range of decision thresholds was narrow. The size of tests that compared areas did not vary from the chosen significance level. Power fell, however, when the variance of area estimates was inflated. I conclude that inferences derived from the binormal assumption are sensitive to model misspecification and to the location of decision thresholds. A narrow span of decision thresholds increases the variability of area estimates and reduces the power of area comparisons. Model misspecification produces bias that alters test size and can exaggerate the loss of power that accompanies increased variability.

摘要

本文关注的是与ROC曲线下面积相关推断的双正态假设的稳健性。我将双正态模型应用于从双逻辑斯蒂曲线采样的评分方法数据集,并观察到面积估计存在小偏差。随着决策阈值范围的减小,偏差增大。面积估计的方差也随着决策阈值范围的减小而增大。小偏差和膨胀的方差共同显著改变了比较双逻辑斯蒂ROC曲线下面积的统计检验的大小和功效。我通过将双正态假设应用于从双正态曲线采样的数据来重复模拟。对于双正态数据,面积估计的偏差最小,但当决策阈值范围较窄时,面积估计的方差再次更高。比较面积的检验大小与选定的显著性水平没有差异。然而,当面积估计的方差膨胀时,功效会下降。我得出结论,从双正态假设得出的推断对模型误设和决策阈值的位置敏感。决策阈值范围较窄会增加面积估计的变异性,并降低面积比较的功效。模型误设会产生偏差,改变检验大小,并可能夸大随着变异性增加而伴随的功效损失。

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