[慢性胰腺炎患者的体液免疫与HLA抗原分布]

[Humoral immunity and the distribution of HLA antigens in patients with chronic pancreatitis].

作者信息

Zhukov N A, Trukhan D I

出版信息

Ter Arkh. 1993;65(2):49-52.

Abstract

132 chronic pancreatitis patients were studied for humoral immunity components and HLA antigens distribution. Antibodies to pancreatic tissue, insulin, o-DNA, d-DNA, n-DNA, ds-RNA were recognized in 44.5, 21.8, 41.8, 29.1, 20.9, 19.1% of chronic pancreatitis patients, respectively. Most pronounced immunological shifts occurred in aggravation of the disease. HLA-antigen typing was indicative of more frequent incidence in chronic pancreatitis patients of antigens HLA A1, B8, B27, Cw1 and less frequent occurrence of antigens A2, Cw4. The results evidence nonuniform etiology and pathogenesis of chronic pancreatitis.

摘要

对132例慢性胰腺炎患者进行了体液免疫成分和HLA抗原分布的研究。慢性胰腺炎患者中，分别有44.5%、21.8%、41.8%、29.1%、20.9%、19.1%的患者检测到胰腺组织抗体、胰岛素抗体、o-DNA抗体、d-DNA抗体、n-DNA抗体、ds-RNA抗体。最明显的免疫变化发生在疾病加重时。HLA抗原分型表明，慢性胰腺炎患者中抗原HLA A1、B8、B27、Cw1的发生率较高，而抗原A2、Cw4的发生率较低。结果证明慢性胰腺炎的病因和发病机制并不统一。