Bartsokas S K, Papadimitriou D G
Endokrinologie. 1977;69(3):321-5.
The effects of hydrocortisone administration in rats intoxicated with one injection of 75 mg galactosamine i.p. per 100 g of body weight are described. Hydrocortisone was given at two schedules; according to the first schedule it was given at the dose of 150 microgram per 100 g of body weight i.p. 1 min before galactosamine administration and after 6 hours at half this dose, while according to the second the animals were pretreated for 24 hours before galactosamine injection at 6 hour intervals four times at the dose of 150 microgram. Both treatments diminished significantly liver cell necrosis induced by galactosamine and lowered serum transaminases activities (P less than 0.001). Liver glycogen depletion and excessive fatty accumulation found in the animals that had received galactosamine alone did not exist after hydrocortisone treatment. The protective hydrocortisone effect is briefly discussed, the present findings remaining unknown.
描述了给每100克体重腹腔注射75毫克半乳糖胺一次造成中毒的大鼠注射氢化可的松的效果。氢化可的松按两种方案给药：按照第一种方案，在注射半乳糖胺前1分钟按每100克体重150微克的剂量腹腔注射，6小时后按该剂量的一半注射；而按照第二种方案，在注射半乳糖胺前24小时，每隔6小时按150微克的剂量腹腔注射4次。两种处理均显著减轻了半乳糖胺诱导的肝细胞坏死，并降低了血清转氨酶活性（P<0.001）。单独接受半乳糖胺的动物出现的肝糖原耗竭和过多脂肪堆积在氢化可的松处理后不复存在。文中简要讨论了氢化可的松的保护作用，目前这些发现尚不清楚。
