Lehmann L E, Guinan E C, Halpern S L, Donovan M J, Bierer B E, Parsons S K
Division of Hematology/Oncology, Children's Hospital, Boston, MA, USA.
Bone Marrow Transplant. 1997 Apr;19(8):849-51. doi: 10.1038/sj.bmt.1700753.
A case of isolated testicular relapse occurring 5 years after allogeneic bone marrow transplantation (BMT) for acute myelogenous leukemia (AML) is reported. The patient presented with M4 AML at age 13 and underwent allogeneic BMT in first remission, 5 months after diagnosis. He had no acute graft-versus-host disease (GVHD) but developed mild chronic GVHD 5 months following transplant and received immunosuppressive therapy for the next 2 years. Five years post-transplant he had an isolated testicular relapse that was treated with chemotherapy and testicular radiation. The patient remains in remission 17 months following relapse and more than 15 months following the cessation of therapy.
报告了1例急性髓系白血病（AML）患者在异基因骨髓移植（BMT）5年后出现孤立性睾丸复发的病例。该患者13岁时诊断为M4型AML，诊断后5个月在首次缓解期接受了异基因BMT。他没有发生急性移植物抗宿主病（GVHD），但在移植后5个月出现了轻度慢性GVHD，并在接下来的2年接受了免疫抑制治疗。移植后5年，他出现了孤立性睾丸复发，接受了化疗和睾丸放疗。该患者在复发后17个月及治疗停止后15个月以上仍处于缓解状态。
