关于使用77Br标记的5α-双氢睾酮扫描前列腺的研究。
Investigations into the use of 77Br labelled 5alpha-dihydrotestosterone for scanning the prostate.
作者信息
Ghanadian R, Waters S L, Chisholm G D
出版信息
Eur J Nucl Med. 1977 Sep 30;2(3):155-7. doi: 10.1007/BF00257273.
The potential use of a potent androgen labelled with a gamma emitting radionuclide for scanning the prostate was investigated. 2alphabromo 5alpha-dihydrotestosterone was synthesized and subsequently labelled with 77Br. The distribution of this compound was studied in rat and human tissues. The maximum concentration of radioactivity in the rat prostate at 1-4 h following the injection was found to be between 0.5-0.8% of the injected dose per gram of the tissue. In the human however, that value was 0.002-0.003%. Considering the overall results it was concluded that this compound is not appropriate for scanning the prostate.
对一种用发射γ射线的放射性核素标记的强效雄激素用于前列腺扫描的潜在用途进行了研究。合成了2α-溴-5α-二氢睾酮，随后用⁷⁷Br进行标记。研究了该化合物在大鼠和人体组织中的分布情况。注射后1至4小时，大鼠前列腺中放射性的最大浓度为每克组织0.5 - 0.8%的注射剂量。然而，在人体中，该值为0.002 - 0.003%。综合总体结果得出结论，该化合物不适合用于前列腺扫描。
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