Jackson A A, Persaud C, Werkmeister G, McClelland I S, Badaloo A, Forrester T
Institute of Human Nutrition, University of Southampton.
Br J Nutr. 1997 Feb;77(2):183-96. doi: 10.1079/bjn19970023.
Urinary 5-L-oxoproline was measured during normal pregnancies in Southampton, England and Kingston, Jamaica. The CV of 5-L-oxoproline excretion in urine, determined over 7 d in a non-pregnant woman and three pregnant women, was 10-36%. Compared with non-pregnant women, urinary 5-L-oxoproline increased three to four times from early pregnancy in women in Southampton, a highly significant difference, and remained elevated at similar levels during mid and late pregnancy. For women in Kingston, the excretion of 5-L-oxoproline was similar to that of Southampton women in the non-pregnant group and during early pregnancy. However, there was a progressive increase in the excretion of 5-L-oxoproline as pregnancy advanced and by late pregnancy excretion was from three to ten times greater than the average for the non-pregnant women. There was a significant difference between the women in Southampton and the women in Kingston during mid and late pregnancy, with women in Kingston excreting twice as much 5-L-oxoproline during late pregnancy. If the excretion of 5-L-oxoproline is a measure of glycine insufficiency, the results would indicate that in some pregnancies the ability of the mother to provide glycine for herself and the developing fetus is marginal or inadequate and the constraint appears more marked in Jamaica than in England.
在英国南安普敦和牙买加金斯敦的正常孕期中对尿中5-L-氧代脯氨酸进行了测量。在一名非孕妇和三名孕妇中，对尿中5-L-氧代脯氨酸排泄量在7天内进行测定，其变异系数为10%-36%。与非孕妇相比，南安普敦女性尿中5-L-氧代脯氨酸从妊娠早期开始增加了三到四倍，差异极为显著，并且在妊娠中期和晚期维持在相似的较高水平。对于金斯敦的女性，在非妊娠组和妊娠早期，5-L-氧代脯氨酸的排泄量与南安普敦女性相似。然而，随着妊娠进展，5-L-氧代脯氨酸的排泄量逐渐增加，到妊娠晚期，排泄量比非孕妇的平均水平高出三到十倍。在妊娠中期和晚期，南安普敦女性和金斯敦女性之间存在显著差异，金斯敦女性在妊娠晚期排泄的5-L-氧代脯氨酸是南安普敦女性的两倍。如果5-L-氧代脯氨酸的排泄量是甘氨酸不足的一个指标，那么结果表明在某些妊娠中，母亲为自身和发育中的胎儿提供甘氨酸的能力处于临界状态或不足，并且这种限制在牙买加比在英国更为明显。
