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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Jackson A A, Badaloo A V, Forrester T, Hibbert J M, Persaud C

Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston, Jamaica.

Br J Nutr. 1987 Sep;58(2):207-14. doi: 10.1079/bjn19870088.

The evidence is accumulating to suggest that glycine, the simplest amino acid, is conditionally essential in man. Benzoic acid, by conjugation with glycine to form hippuric acid, is known to deplete the free glycine pool of the body. Glycine is one substrate for the enzyme glutathione synthase (EC 6.3.2.3) and in the inborn error of metabolism in which glutathione synthase function is defective, increased quantities of 5-oxoproline are excreted in the urine. 2. An oral dose of 4-10 g sodium benzoate was given to six normal adults to deplete the metabolic pool of glycine, and the urinary excretion of 5-oxoproline was followed for 6 h. In five of the six, a significant increase in the urinary 5-oxoproline was seen within 3 h. 3. These findings show that 5-oxoprolinuria can result from limited glycine availability, and may provide a useful test for assessing glycine sufficiency in a range of physiological and pathological states.

越来越多的证据表明，最简单的氨基酸甘氨酸在人体中是条件必需的。苯甲酸通过与甘氨酸结合形成马尿酸，已知会耗尽人体的游离甘氨酸池。甘氨酸是谷胱甘肽合酶（EC 6.3.2.3）的一种底物，在谷胱甘肽合酶功能有缺陷的先天性代谢异常中，尿中5-氧代脯氨酸的排泄量会增加。2. 给6名正常成年人口服4-10克苯甲酸钠以耗尽甘氨酸的代谢池，并对尿中5-氧代脯氨酸的排泄情况进行了6小时的跟踪。在6人中的5人身上，在3小时内尿中5-氧代脯氨酸出现了显著增加。3. 这些发现表明，5-氧代脯氨酸尿症可能是由于甘氨酸供应有限导致的，并且可能为评估一系列生理和病理状态下的甘氨酸充足情况提供一种有用的检测方法。

Jackson A A, Badaloo A V, Forrester T, Hibbert J M, Persaud C

Tropical Metabolism Research Unit, University of the West Indies, Mona, Kingston, Jamaica.

Br J Nutr. 1987 Sep;58(2):207-14. doi: 10.1079/bjn19870088.

The evidence is accumulating to suggest that glycine, the simplest amino acid, is conditionally essential in man. Benzoic acid, by conjugation with glycine to form hippuric acid, is known to deplete the free glycine pool of the body. Glycine is one substrate for the enzyme glutathione synthase (EC 6.3.2.3) and in the inborn error of metabolism in which glutathione synthase function is defective, increased quantities of 5-oxoproline are excreted in the urine. 2. An oral dose of 4-10 g sodium benzoate was given to six normal adults to deplete the metabolic pool of glycine, and the urinary excretion of 5-oxoproline was followed for 6 h. In five of the six, a significant increase in the urinary 5-oxoproline was seen within 3 h. 3. These findings show that 5-oxoprolinuria can result from limited glycine availability, and may provide a useful test for assessing glycine sufficiency in a range of physiological and pathological states.

越来越多的证据表明，最简单的氨基酸甘氨酸在人体中是条件必需的。苯甲酸通过与甘氨酸结合形成马尿酸，已知会耗尽人体的游离甘氨酸池。甘氨酸是谷胱甘肽合酶（EC 6.3.2.3）的一种底物，在谷胱甘肽合酶功能有缺陷的先天性代谢异常中，尿中5-氧代脯氨酸的排泄量会增加。2. 给6名正常成年人口服4-10克苯甲酸钠以耗尽甘氨酸的代谢池，并对尿中5-氧代脯氨酸的排泄情况进行了6小时的跟踪。在6人中的5人身上，在3小时内尿中5-氧代脯氨酸出现了显著增加。3. 这些发现表明，5-氧代脯氨酸尿症可能是由于甘氨酸供应有限导致的，并且可能为评估一系列生理和病理状态下的甘氨酸充足情况提供一种有用的检测方法。