Hirano K, Itoh Y, Horiguchi M, Miyake Y, Awaya S
Department of Ophthalmology, Nagoya University School of Medicine, Aichi-ken, Japan.
Nippon Ganka Gakkai Zasshi. 1997 Apr;101(4):327-34.
We performed indocyanine green angiography (ICG angiography) and fluorescein angiography in order to investigate the choroidal circulation in patients with Stargardt's flavimaculatus. Eight eyes of 4 patients in Groups 2 approximately 3 (Noble classification) were included in this study. In the area with "dark choroid" in fluorescein angiography, ICG angiography revealed large choroidal vessels in all eyes, but some fluorescent choroidal vessels were dark around the atrophic macula and in the peripapillary area, which indicated a greater storage of lipofuscin within the retinal pigment epithelium in those areas. In the atrophic macula area, irregular hypofluorescence was observed in ICG angiography, which might be caused by filling defect and/or block. Many flecks revealed hyperfluorescence in fluorescein angiography and hypofluorescence in ICG angiography, suggesting that focal circulatory disturbances in the choriocapillaries exist beneath the flecks.
我们进行了吲哚菁绿血管造影(ICG血管造影)和荧光素血管造影,以研究Stargardt黄斑营养不良患者的脉络膜循环。本研究纳入了2至3组(诺布尔分类)4例患者的8只眼。在荧光素血管造影显示“脉络膜暗区”的区域,ICG血管造影显示所有眼中均有粗大的脉络膜血管,但在萎缩性黄斑周围和视乳头周围区域,一些荧光脉络膜血管较暗,这表明这些区域的视网膜色素上皮细胞内脂褐素储存较多。在萎缩性黄斑区域,ICG血管造影观察到不规则的低荧光,这可能是由于充盈缺损和/或阻塞所致。许多斑点在荧光素血管造影中显示高荧光,而在ICG血管造影中显示低荧光,提示斑点下方的脉络膜毛细血管存在局灶性循环障碍。