Williams B P, Park J K, Alberta J A, Muhlebach S G, Hwang G Y, Roberts T M, Stiles C D
Department of Microbiology and Molecular Genetics, Harvard Medical School and the Dana Farber Cancer Institute, Boston, Massachusetts 02115, USA.
Neuron. 1997 Apr;18(4):553-62. doi: 10.1016/s0896-6273(00)80297-4.
When exposed to platelet-derived growth factor (PDGF), uncommitted neuroepithelial cells from the developing cortex of embryonic day 14 (E14) rats develop into neurons. Outward signs of the neuronal phenotype are not observed for 4 days following exposure to PDGF. However, only a brief (2-3 hr) period of PDGF receptor activation is required to initiate neuronal development. During the window of receptor activation, RNA synthesis is essential, but protein synthesis is not. These observations indicate that specification of neuronal fate is mediated by an immediate early gene response.
当暴露于血小板衍生生长因子（PDGF）时，来自胚胎第14天（E14）大鼠发育中皮层的未分化神经上皮细胞会发育成神经元。暴露于PDGF后4天内未观察到神经元表型的外在迹象。然而，启动神经元发育仅需要短暂（2 - 3小时）的PDGF受体激活期。在受体激活期内，RNA合成是必需的，但蛋白质合成不是。这些观察结果表明，神经元命运的特化是由即刻早期基因反应介导的。
