Sakagami H, Satoh K, Aiuchi T, Nakaya K, Takeda M
Department of Biochemistry, School of Medicine, Showa University, Tokyo, Japan.
Anticancer Res. 1997 Mar-Apr;17(2A):1213-6.
Alkali-lignin, lignin sulfonate or protein-bound polysaccharide (PSK) significantly enhanced the ascorbyl radical intensity and cytotoxic activity of ascorbate, but inhibited the intracellular incorporation of [14C]ascorbic acid. These natural products also enhanced ascorbate-induced oxygen consumption, resulting in the rapid depletion of oxygen from culture medium. Enhancement of oxygen consumption was coupled with elevation of oxidation potential. These data suggest that lignin and PSK stimulate the cytotoxic activity of ascorbate by hypoxia.
碱木质素、木质素磺酸盐或蛋白结合多糖（PSK）显著增强了抗坏血酸自由基强度和抗坏血酸盐的细胞毒性活性，但抑制了[14C]抗坏血酸的细胞内摄取。这些天然产物还增强了抗坏血酸盐诱导的氧气消耗，导致培养基中的氧气迅速耗尽。氧气消耗的增强与氧化电位的升高相关。这些数据表明，木质素和PSK通过缺氧刺激抗坏血酸盐的细胞毒性活性。
