Satoh K, Sakagami H
Analysis Center, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan.
Anticancer Res. 1996 Sep-Oct;16(5A):2885-90.
A variety of tannin and lignin-related compounds were compared for their ability to modify the ascorbyl radical intensity of sodium ascorbate. Hot-water extracts prepared from green tea, black tea and pine cone (Pinus parviflora Sieb. et Zucc.), and various wines potently scavenged ascorbyl radical intensity. Low molecular weight tannins and phenylpropenoid monomers showed the greatest scavenging activity, whereas the dehydrogenation polymers of phenylpropenoids were much less active. On the other hand, natural lignified materials, protein-bound polysaccharide (PSK) and positively-charged glucans enhanced the ascorbyl radical intensity. Lignin sulfonate stimulated the sodium ascorbate-induced cytotoxicity in human promyelocytic leukemic HL-60 cells. These data suggest that the ascorbyl radical scavenging activity of polyphenols depends on molecular weight, the functional group and the presence of polysaccharides in the molecule.
比较了多种与单宁和木质素相关的化合物改变抗坏血酸钠抗坏血酸自由基强度的能力。从绿茶、红茶和松果（赤松）制备的热水提取物以及各种葡萄酒能有效清除抗坏血酸自由基强度。低分子量单宁和苯丙素类单体表现出最大的清除活性，而苯丙素类的脱氢聚合物活性则低得多。另一方面，天然木质化材料、蛋白结合多糖（PSK）和带正电荷的葡聚糖增强了抗坏血酸自由基强度。木质素磺酸盐可刺激抗坏血酸钠诱导的人早幼粒白血病HL-60细胞的细胞毒性。这些数据表明，多酚的抗坏血酸自由基清除活性取决于分子量、官能团以及分子中多糖的存在情况。
