Lai Y C, Friends G D
Contact Lens Division, Bausch & Lomb Inc., Rochester, New York 14692, USA.
J Biomed Mater Res. 1997 Jun 5;35(3):349-56. doi: 10.1002/(sici)1097-4636(19970605)35:3<349::aid-jbm9>3.0.co;2-h.
In the quest for hydrogel contact lenses with improved extended wear capability, the use of siloxane moieties in the lens materials was investigated. However, the introduction of hydrophobic siloxane groups gave rise to wettability and lipidlike deposit problems. It was found that when polysiloxane-based compositions for hydrogels were processed with polar plastic molds, such as those fabricated from an acrylonitrile-based polymer, the hydrogel lenses fabricated were wettable, with minimized lipidlike deposits. These findings were supported by the wettability of silicone hydrogel films, silicon, and nitrogen element contents near lens surfaces, as well as the results from clinical assessment of silicone hydrogel lenses.
在寻求具有改善的长戴能力的水凝胶隐形眼镜的过程中，研究了在镜片材料中使用硅氧烷基团。然而，疏水性硅氧烷基团的引入导致了润湿性和类脂沉积物问题。研究发现，当用于水凝胶的基于聚硅氧烷的组合物用极性塑料模具加工时，例如由丙烯腈基聚合物制成的模具，所制造的水凝胶镜片具有可润湿性，且类脂沉积物最少。这些发现得到了硅水凝胶膜的润湿性、镜片表面附近的硅和氮元素含量以及硅水凝胶镜片临床评估结果的支持。
