Hohenleutner U, Hohenleutner S, Bäumler W, Landthaler M
Department of Dermatology, University of Regensburg, Germany.
Lasers Surg Med. 1997;20(3):242-7. doi: 10.1002/(sici)1096-9101(1997)20:3<242::aid-lsm2>3.0.co;2-q.
Er:YAG lasers are known to superficially ablate skin and other tissues with minimal thermal coagulation zones. The ablation efficacy and thus the clinical applicability of these lasers, however, was limited due to small beam diameters and repetition rates. Aim of this study was to determine the ablation efficacy and the amount of thermal damage with a new high-power high-repetition-rate Er:YAG laser and to find optimal treatment parameters for skin ablation.
STUDY DESIGN/MATERIALS AND METHODS: In vitro and some in vivo ablation trials on human skin were performed with the Er:YAG laser (MCL 29, Aesculap-Meditec, Heroldsberg, Germany, 2.94 microns, max. 500 mJ per pulse, 250 microseconds pulse length, 3 or 4 mm spot size, repetition rate 7-10 Hz) and evaluated microscopically.
The ablation threshold was around 1.6 J/cm2. The ablation rates increased linearly with the fluence, and the above-threshold ablation efficacy was around 2.5 microns per pulse per J/cm2, leading to ablation velocities of 70-100 microns per second and higher. With increasing pulse numbers applied to one tissue spot, the ablation per pulse decreased significantly. The amount of thermal damage was clearly dependent on the number of pulses applied (around 25 microns with < 10 imp., up to 100 microns with 40 imp.), whereas higher fluences increased the coagulation zones only minimally. The in vivo trials confirmed these results: overlapping pulses in the 4 J/cm2-range, applied in a sweeping motion, proved optimal for an efficient skin ablation with a smooth resulting surface and a thermal damage zone not exceeding 50 microns.
The high power and the high repetition frequency make this laser a fast and effective tool for skin ablation without increasing the thermal damage, but the ablation remains limited to the superficial dermis, since hemostasis cannot be achieved due to the absence of coagulation.
铒激光以极小的热凝固区域对皮肤和其他组织进行表面消融而闻名。然而,由于光束直径小和重复频率低,这些激光的消融效果以及临床适用性受到限制。本研究的目的是使用新型高功率高重复频率铒激光确定其消融效果和热损伤量,并找到皮肤消融的最佳治疗参数。
研究设计/材料与方法:使用铒激光(MCL 29,德国赫罗尔德斯贝格蛇牌美迪泰克公司,波长2.94微米,每脉冲最大500毫焦,脉冲长度250微秒,光斑尺寸3或4毫米,重复频率7 - 10赫兹)对人体皮肤进行体外及部分体内消融试验,并进行显微镜评估。
消融阈值约为1.6焦/平方厘米。消融速率随能量密度呈线性增加,阈值以上的消融效果约为每焦耳/平方厘米每脉冲2.5微米,导致消融速度达到每秒70 - 100微米甚至更高。随着施加到一个组织点的脉冲数增加,每个脉冲的消融量显著下降。热损伤量明显取决于施加的脉冲数(小于10次脉冲时约为25微米,40次脉冲时可达100微米),而较高的能量密度仅使凝固区域略有增加。体内试验证实了这些结果:以扫动方式施加4焦/平方厘米范围内的重叠脉冲,被证明是高效皮肤消融的最佳方式,可形成光滑的表面且热损伤区域不超过50微米。
高功率和高重复频率使该激光成为皮肤消融的快速有效工具,且不会增加热损伤,但由于缺乏凝固作用无法实现止血,消融仍局限于浅表真皮层。