关于肌原纤维僵硬度的理论思考。

Theoretical considerations on myofibril stiffness.

作者信息

Forcinito M, Epstein M, Herzog W

机构信息

Department of Mechanical Engineering, University of Calgary, Alberta, Canada.

出版信息

Biophys J. 1997 Mar;72(3):1278-86. doi: 10.1016/S0006-3495(97)78774-5.

DOI:10.1016/S0006-3495(97)78774-5

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1184510/

Abstract

A discrete model of the interaction between individual myofilaments was developed to study the stiffness of a sarcomere for the case in which filament compliance is not negligible. Our model retains, in the limit, the characteristics of the previously published model by Ford et al. (Ford, L. E., A. F. Huxley, and R. M. Simmons. 1981. The relation between stiffness and filament overlap in stimulated frog muscle fibres. J. Physiol. 311:219-249). In addition, the model is able to model the interaction in cases in which few cross-bridges are attached, or when the distribution of attached cross-bridges is not uniform. Our results confirm previous indications that it might be impossible to calculate the number of attached cross-bridges by using only stiffness measurements in quick-stretch (or release) experiments.

摘要

为了研究细丝顺应性不可忽略情况下肌节的刚度，建立了单个肌丝间相互作用的离散模型。在极限情况下，我们的模型保留了福特等人（福特，L.E.，A.F.赫胥黎和R.M.西蒙斯。1981年。刺激的青蛙肌肉纤维中刚度与细丝重叠的关系。《生理学杂志》311:219 - 249）之前发表的模型的特征。此外，该模型能够模拟附着的横桥很少或附着横桥分布不均匀情况下的相互作用。我们的结果证实了之前的迹象，即在快速拉伸（或释放）实验中仅使用刚度测量可能无法计算附着横桥的数量。

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Biophys J. 1995 Sep;69(3):1000-10. doi: 10.1016/S0006-3495(95)79975-1.

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Proc Natl Acad Sci U S A. 1994 Dec 20;91(26):12962-6. doi: 10.1073/pnas.91.26.12962.

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Biophys J. 1994 Dec;67(6):2411-21. doi: 10.1016/S0006-3495(94)80728-3.

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