Gil M L, Pérez-Jaranay J M, Pérez-Albacete M, Noguera J A, Tovar I, Martínez P
Servicio de Análisis Clínicos, Hospital Universitario Virgen de la Arrixaca, Murcia.
Actas Urol Esp. 1996 Nov-Dec;20(10):877-82.
Basic semen tests nowadays contain no variables that may allow to certify that a man is fertile. Starting from this premise it could be clinically very useful, for the diagnosis of male infertility, to evaluate a parameter that may be related to sexual maturity and be specific of the germinal tissue, such as the C4-lactate dehydrogenase isoenzyme (C4-LDH), which could indicate the activity of the germinal epithelium and the quality of the spermatozoa. In our experience, C4-LDH activity in seminal plasma discriminates between fertile and non-fertile males; also, their testicular study has a good correlation both with histologically diagnosed disease and the seminal plasma levels. All of which suggest the diagnostic validity of plasma C4-LDH in male infertility, as a routine test which thus precludes the use of invasive techniques in the patient.
如今的基本精液检测不包含任何能够用以证明男性具有生育能力的变量。基于这一前提，对于男性不育症的诊断而言，评估一个可能与性成熟相关且为生发组织所特有的参数，比如C4 - 乳酸脱氢酶同工酶（C4 - LDH），在临床上可能会非常有用，它可以指示生精上皮的活性以及精子的质量。根据我们的经验，精浆中的C4 - LDH活性能够区分可育和不育男性；此外，对他们睾丸的研究与组织学诊断的疾病以及精浆水平都具有良好的相关性。所有这些都表明精浆C4 - LDH在男性不育症诊断中的有效性，作为一项常规检测，从而避免了对患者使用侵入性技术。
