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实验性维生素A过多症时甲状腺腺瘤样结节中C细胞的超微结构

Ultrastructure of the C cells forming adenoma-like nodules of the thyroid in experimental hypervitaminosis A.

作者信息

Roszkiewicz J, Roszkiewicz A

出版信息

Gegenbaurs Morphol Jahrb. 1977;123(1):18-30.

PMID:913995
Abstract

The degranulation of the C cells, their hypertrophy and hyperplasia leading to the formation adenoma-like nodules were observed under conditions of prolonged hypervitaminosis A which causes bone damage without associated hypercalcemia. These changes which are probably the morphologic manifestation of the increased requirement of the body for calcitonin, connected with the damage of the bone tissue seem to indicate that calcitonin is an important factor essential for the protection of skeleton from its excessive mineralization.

摘要

在长期维生素A过多症导致骨损伤但无相关高钙血症的情况下,观察到C细胞脱颗粒、肥大和增生,导致形成腺瘤样结节。这些变化可能是机体对降钙素需求增加的形态学表现,与骨组织损伤有关,似乎表明降钙素是保护骨骼免于过度矿化的重要因素。

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