Zabel M
Endokrinologie. 1976 Jul;67(3):315-21.
Long-term hypercalcemia induced in rats by administration of vitamine D3 and CaCl2 for 60 days resulted in strong hyperplasia and hypertrophy of C-cells. The extent of hyperplasia varied greatly in individual animals. Histochemical reactions, especially the masked metachromasy with toluidine blue, demonstrated cell groups in which no reaction was observed beside those exhibiting a very strong reaction. Impregnation with silver according to Cajal showed a diminished number of argyrophilic granules in the C-cells, which had undergone hyperplasia. The reactions for non-specific esterases and cholinesterases were similar both in the experimental animals and in the controls. An enlargement of the C-cell nuclei in the experimental group was also pronounced. The total serum calcium level was only slightly increased in this group. It is concluded that the results of staining and the enlargement in nuclear volume of C-cells reflect the increased activity of these cells. Hyperplasia of the C-cells may represent a type of adaptation of the endocrine system in order to maintain calcium homeostasis.
给大鼠连续60天给予维生素D3和氯化钙诱导长期高钙血症，导致C细胞强烈增生和肥大。个体动物的增生程度差异很大。组织化学反应，尤其是甲苯胺蓝的隐蔽异染性，显示出细胞群，除了那些显示出非常强烈反应的细胞群外，没有观察到反应。根据 Cajal 法进行的银浸染显示，增生的C细胞中嗜银颗粒数量减少。实验组和对照组中非特异性酯酶和胆碱酯酶的反应相似。实验组中C细胞核的增大也很明显。该组血清总钙水平仅略有升高。结论是，C细胞染色结果和核体积增大反映了这些细胞活性的增加。C细胞增生可能代表内分泌系统为维持钙稳态的一种适应类型。
