Ryan L K, Foster F S
Sunnybrook Health Science Centre, Department of Medical Biophysics, University of Toronto, Ontario, Canada.
Ultrasound Med Biol. 1997;23(2):261-73. doi: 10.1016/s0301-5629(96)00206-2.
A tissue equivalent arterial vessel phantom has been developed for use in intravascular ultrasound imaging studies. The phantom material is constructed from a cross-linked gelatin matrix to which amorphous silica scattering particles are added. The ultrasonic properties (speed of sound, frequency-dependent attenuation coefficient and frequency-dependent backscatter coefficient) of the phantom material have been characterized at 42 MHz and correspond well with in vitro measurements of excised human arterial tissue. The mechanical properties of the cast vessel phantoms are controlled by varying the concentration of gelatin used in the matrix. Experimentally measured values of the circumferential Young's elastic modulus of hard and soft vessel phantoms agree well with values reported in the literature for human and canine arterial tissue for transmural pressures up to 100 mmHg. The phantoms are therefore suitable models for use in the development of new applications of intravascular ultrasound imaging, such as the assessment regional arterial elasticity.
一种用于血管内超声成像研究的组织等效动脉血管模型已被开发出来。该模型材料由交联明胶基质构成，并添加了无定形二氧化硅散射颗粒。已在42兆赫兹下对该模型材料的超声特性（声速、频率相关衰减系数和频率相关背向散射系数）进行了表征，其结果与切除的人体动脉组织的体外测量结果吻合良好。通过改变基质中使用的明胶浓度来控制铸型血管模型的力学性能。对于高达100毫米汞柱的跨壁压力，硬血管模型和软血管模型的周向杨氏弹性模量的实验测量值与文献中报道的人体和犬类动脉组织的值吻合良好。因此，这些模型适用于血管内超声成像新应用的开发，比如评估局部动脉弹性。
