Tominaga M, Ohya Y, Tsukashima A, Kobayashi K, Takata Y, Koga T, Yamashita Y, Fujishima Y, Abe I, Fujishima M
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Cardiovasc Drugs Ther. 1997 Mar;11(1):43-8. doi: 10.1023/a:1007795722576.
Cilnidipine (FRC-8653), a new dihydropyridine calcium antagonist, was given to 14 hospitalized patients with essential hypertension, and 24-hour ambulatory blood pressure (BP) monitoring was performed. Once-daily administration of cilnidipine (5-20 mg) for 1-3 weeks decreased the 24-hour average BP significantly from 149 +/- 4/88 +/- 2 mmHg to 141 +/- 3/82 +/- 2 mmHg without any change in the pulse rate. The decrease in ambulatory BP by cilnidipine was evident during the daytime (156 +/- 4/93 +/- 2 mmHg to 143 +/- 5/84 +/- 2 mmHg, p < 0.01 for systolic BP and p < 0.01 for diastolic BP), while it was mild during nighttime (141 +/- 4/80 +/- 2 mmHg to 133 +/- 4/76 +/- 3 mmHg, p < 0.05 for systolic and ns for diastolic BP). The decrease in the ambulatory BP over the whole day and during the nighttime was significantly correlated with the basal ambulatory BP levels. When the subjects were divided into the high ambulatory BP (n = 7) and low ambulatory BP (n = 7) groups, the BP reduction by cilnidipine was evident throughout 24 hours in the high ambulatory BP group, while it was mild and significant only during daytime in the low ambulatory BP group. In summary, once-daily cilnidipine exerts a sufficient and prolonged reduction of BP without an increase in the pulse rate in patients with hypertension. The potency of cilnidipine to decrease ambulatory BP may depend on the basal ambulatory BP level. Cilnidipine is thus a useful antihypertensive drug that may not cause an excessive decrease in BP or a reflex tachycardia.
西尼地平（FRC - 8653），一种新型二氢吡啶类钙拮抗剂，给予14例住院原发性高血压患者，并进行24小时动态血压监测。每日一次服用西尼地平（5 - 20毫克），持续1 - 3周，可使24小时平均血压从149±4/88±2毫米汞柱显著降至141±3/82±2毫米汞柱，而脉率无任何变化。西尼地平使动态血压在白天明显下降（从156±4/93±2毫米汞柱降至143±5/84±2毫米汞柱，收缩压p<0.01，舒张压p<0.01），而在夜间下降较轻微（从141±4/80±2毫米汞柱降至133±4/76±3毫米汞柱，收缩压p<0.05，舒张压无统计学意义）。全天和夜间动态血压的下降与基础动态血压水平显著相关。当将受试者分为高动态血压组（n = 7）和低动态血压组（n = 7）时，西尼地平在高动态血压组24小时内血压降低明显，而在低动态血压组仅在白天降低轻微且有统计学意义。总之，每日一次服用西尼地平可使高血压患者血压充分且持久降低，而脉率不增加。西尼地平降低动态血压的效力可能取决于基础动态血压水平。因此，西尼地平是一种有用的抗高血压药物，可能不会导致血压过度降低或反射性心动过速。
