人类皮质醇诱导性高血压中的反射性交感神经功能

Reflex sympathetic function in cortisol-induced hypertension in humans.

作者信息

Tam S H, Kelly J J, Williamson P M, Whitworth J A

机构信息

Department of Medicine, University of New South Wales, St George Hospital, Sydney.

出版信息

Clin Exp Hypertens. 1997 May;19(4):479-93. doi: 10.3109/10641969709084509.

DOI:10.3109/10641969709084509

PMID:9140709

Abstract

Nine healthy male subjects underwent measurement of reflex sympathetic function, pressor responsiveness and baroreflex sensitivity to phenylephrine (PE) and glyceryltrinitrate (GTN) before (C1) and following six days of treatment (E6) with cortisol (F), 200 mg/day. Seven subjects had washout studies (W) performed at least two weeks following the end of treatment. The BP responses to head tilt, isometric exercise and mental arithmetic were unaltered by F, however, there was a significant diminution of the diastolic BP response to cold pressor stimulus (delta DBP: 19 +/- 3 vs 25 +/- 5 vs 27 +/- 5 mmHg; E6 vs C1 vs W, p < 0.05 C1 vs E6 and W). Baroreflex sensitivity to PE was increased (28 +/- 3 vs 19 +/- 2 ms/mmHg, E6 vs C1, p = 0.03). These data demonstrate that increased BP during F treatment is not attributable to increased SNS activity, and suggest that SNS activity may be decreased by F.

摘要

9名健康男性受试者在接受每天200毫克皮质醇（F）治疗前（C1）和治疗6天后（E6），接受了对去氧肾上腺素（PE）和硝酸甘油（GTN）的反射性交感神经功能、升压反应性和压力反射敏感性的测量。7名受试者在治疗结束后至少两周进行了洗脱研究（W）。F对头部倾斜、等长运动和心算的血压反应没有改变，然而，对冷加压刺激的舒张压反应显著降低（舒张压变化值：19±3 vs 25±5 vs 27±5 mmHg；E6 vs C1 vs W，C1与E6和W相比，p<0.05）。对PE的压力反射敏感性增加（28±3 vs 19±2毫秒/毫米汞柱，E6 vs C1，p=0.03）。这些数据表明，F治疗期间血压升高并非归因于交感神经系统（SNS）活动增加，提示F可能会降低SNS活动。