放疗期间采用体内氢磁共振波谱技术对脑肿瘤中乳酸（+脂质）浓度的变化进行研究。
Alterations of lactate (+lipid) concentration in brain tumors with in vivo hydrogen magnetic resonance spectroscopy during radiotherapy.
作者信息
Tomoi M, Kimura H, Yoshida M, Itoh S, Kawamura Y, Hayashi N, Yamamoto K, Kubota T, Ishii Y
机构信息
Department of Radiology, Fukui Medical School, Japan.
出版信息
Invest Radiol. 1997 May;32(5):288-96. doi: 10.1097/00004424-199705000-00006.
RATIONALE AND OBJECTIVES
The authors determine whether assessment of the relative lactate(+lipid) concentration ([r-Lac(+lip)]) obtained from hydrogen magnetic resonance (MR) spectroscopy is useful for predicting the outcome of radiotherapy on brain tumors.
METHODS
Fifty-one hydrogen MR spectroscopic studies were performed in eight patients with primary or metastatic brain tumor before and during radiotherapy. The r-Lac(+lip) calculated as the ratio of lactate(+lipid) peak area to total water was compared before and during radiotherapy in each case. The change of tumor volume measured on magnetic resonance images also was compared.
RESULTS
The r-Lac(+lip) substantially decreased in the radiosensitive cases (three lymphomas and one brain cancer) but did not decrease, even at the end of therapy, in the radioresistant cases (two brain cancers and two glioblastomas).
CONCLUSION
Assessment of r-Lac(+lip) may adjunctively contribute to the early prediction of the radiotherapeutic effect on brain tumors.
原理与目的
作者确定通过氢磁共振波谱法获得的相对乳酸（+脂质）浓度（[r-Lac(+lip)]）评估是否有助于预测脑肿瘤放疗的效果。
方法
在8例原发性或转移性脑肿瘤患者放疗前及放疗期间进行了51次氢磁共振波谱研究。计算每种情况下放疗前及放疗期间乳酸（+脂质）峰面积与总水的比值，即r-Lac(+lip)。还比较了磁共振图像上测量的肿瘤体积变化。
结果
在放射敏感病例（3例淋巴瘤和1例脑癌）中，r-Lac(+lip)显著降低，但在放射抵抗病例（2例脑癌和2例胶质母细胞瘤）中，即使在治疗结束时也未降低。
结论
r-Lac(+lip)评估可能有助于早期预测脑肿瘤的放射治疗效果。
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