Frick E, Stickl H
Fortschr Med. 1977 Oct 6;95(37):2235-41.
In 79 of 100 patients with multiple sclerosis, serum antibodies of the IgG type were demonstrated which render normal lymphocytes cytotoxic against basic protein of myelin. In 11 cerebrospinal fluids which were tested the antibody was also found. The method used was the release of 51Cr from chicken erythrocytes coated with antigen. The antibody-dependent lymphocyte cytotoxicity is related to the degree of activity of the disease and not to the evolution of the disease or its course. As the disease worsens, the frequency of positive reactions is higher than in inactive stages. The immunological reaction is very specific for multiple sclerosis, in patients with other neurological disorders only 5% had positive findings. The antibody-dependent cytotoxicity of lymphocytes against basic protein of myelin may be attributed with a certain diagnostic significance. The reaction seems suitable for the supervision of the course of multiple sclerosis and to check the effect of therapeutic measures. The antibody-dependent lymphocyte cytotoxicity against basic protein of myelin is considered to be significant in the pathogenesis of multiple sclerosis.
在100例多发性硬化症患者中，有79例检测到IgG型血清抗体，该抗体可使正常淋巴细胞对髓鞘碱性蛋白产生细胞毒性。在检测的11份脑脊液中也发现了这种抗体。所采用的方法是从包被有抗原的鸡红细胞中释放51Cr。抗体依赖性淋巴细胞细胞毒性与疾病的活动程度有关，而与疾病的进展或病程无关。随着疾病恶化，阳性反应的频率高于非活动期。这种免疫反应对多发性硬化症具有高度特异性，在其他神经系统疾病患者中只有5%有阳性结果。淋巴细胞对髓鞘碱性蛋白的抗体依赖性细胞毒性可能具有一定的诊断意义。该反应似乎适用于监测多发性硬化症的病程以及检查治疗措施的效果。淋巴细胞对髓鞘碱性蛋白的抗体依赖性细胞毒性被认为在多发性硬化症的发病机制中具有重要意义。
