Maida E
J Neurol. 1983;229(2):103-11. doi: 10.1007/BF00313449.
Humoral and cellular immune reactions against Mycoplasma pneumoniae (MPn) were investigated in 18 multiple sclerosis (MS) patients. All patients were in the remission stage. Complement-fixing antibodies against MPn were present in serum and cerebrospinal fluid, concentrated to contain the same protein levels. The CSF titres after concentration were as high as or higher than the corresponding serum titres, thus indicating intrathecal antibody production. Sensitization to MPn was demonstrable in all 18 MS patients by the antigen-reactive active E-rosette assay and antibody-dependent cellular cytotoxicity assay, in 17 of the 18 patients by the lymphocyte transformation test and in 8 patients by the cell-mediated cytotoxicity assay. The possibility of a pathogenetic role of MPn for MS is discussed.
对18例多发性硬化症（MS）患者进行了针对肺炎支原体（MPn）的体液免疫和细胞免疫反应研究。所有患者均处于缓解期。血清和脑脊液中均存在针对MPn的补体结合抗体，浓缩后所含蛋白质水平相同。浓缩后的脑脊液滴度与相应血清滴度一样高或更高，表明存在鞘内抗体产生。通过抗原反应性活性E花环试验和抗体依赖性细胞毒性试验，在所有18例MS患者中均证实对MPn致敏；通过淋巴细胞转化试验，在18例患者中的17例中证实致敏；通过细胞介导的细胞毒性试验，在8例患者中证实致敏。本文讨论了MPn在MS发病机制中发挥作用的可能性。
