Noguchi S, Sata M, Suzuki H, Ohba K, Mizokami M, Tanikawa K
Second Department of Medicine, Kurume University School of Medicine, Asahi-Machi, Japan.
Clin Infect Dis. 1997 May;24(5):992-4. doi: 10.1093/clinids/24.5.992.
Because there is no effective neutralizing antibody or vaccine for preventing hepatitis C virus (HCV) transmission, HCV can be transmitted to health care workers through accidental needlesticks. Recently, two of our health care workers acquired HCV infection through needlestick accidents and developed acute hepatitis C. The route of transmission was confirmed by molecular evolutionary analysis with use of the E2 region of the HCV genome. After the clinical onset of acute hepatitis, the health care workers were treated with interferon (IFN) (total dose, approximately 300 megaunits). Neither individual developed chronic hepatitis. This finding raises the possibility that treatment with low-dose IFN following an accidental needlestick may be beneficial, even when it is started after the clinical onset of hepatitis.
由于目前尚无有效的中和抗体或疫苗可预防丙型肝炎病毒（HCV）传播，HCV可通过意外针刺传播给医护人员。最近，我们的两名医护人员因针刺事故感染了HCV并发展为急性丙型肝炎。通过对HCV基因组E2区域进行分子进化分析，证实了传播途径。急性肝炎临床发病后，这两名医护人员接受了干扰素（IFN）治疗（总剂量约300兆单位）。两人均未发展为慢性肝炎。这一发现提示，即使在肝炎临床发病后开始使用低剂量IFN进行治疗，意外针刺后进行该治疗可能也是有益的。
