Brundin T
Department of Clinical Physiology, Karolinska Hospital, Stockholm, Sweden.
Am J Physiol. 1998 Apr;274(4):E684-91. doi: 10.1152/ajpendo.1998.274.4.E684.
Relatively few studies on the physiological effects of fat administration have been published. In the present study, whole body and splanchnic oxygen consumption, blood flow, blood temperature, glucose and insulin economy, and arterial and hepatic venous concentrations of hemoglobin, free fatty acids (FFA), and glycerol were measured by indirect calorimetry and catheterization technique in seven healthy men before and during 2.5 h after oral ingestion of 850 kJ of fat and in five healthy men before and during a 2.5-h intravenous (i.v.) infusion of 850 kJ of fat. Oral fat increased the splanchnic blood flow by 57 +/- 25%, reduced the plasma volume by 6 +/- 1%, reduced the arterial concentrations of FFA and glycerol by 33 +/- 7 and 50 +/- 16%, respectively, and increased arterial insulin concentration by 52 +/- 12% despite a simultaneous reduction in splanchnic insulin release, thus suggesting a reduction of the extrasplanchnic extraction of insulin. None of these effects occurred during intravenous fat infusion, and it is suggested that intestinal hormones might elicit these effects. Body heat content, unaffected after oral fat, increased by 67 +/- 20 kJ during intravenous fat infusion.
关于脂肪摄入的生理效应的研究相对较少。在本研究中，通过间接量热法和导管插入技术，在7名健康男性口服850千焦脂肪之前及之后2.5小时内，以及在5名健康男性静脉输注850千焦脂肪之前及2.5小时输注期间，测量了全身和内脏的氧消耗、血流量、体温、葡萄糖和胰岛素代谢，以及动脉血和肝静脉血中血红蛋白、游离脂肪酸（FFA）和甘油的浓度。口服脂肪使内脏血流量增加了57±25%，使血浆量减少了6±1%，使动脉血中FFA和甘油的浓度分别降低了33±7%和50±16%，并使动脉胰岛素浓度增加了52±12%，尽管同时内脏胰岛素释放减少，这表明胰岛素的肝外摄取减少。静脉输注脂肪期间未出现这些效应，提示肠道激素可能引发这些效应。口服脂肪后身体热量含量未受影响，静脉输注脂肪期间增加了67±20千焦。
