Jorgensen J S, Geoly F J, Berry C R, Breuhaus B A
Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh 27606, USA.
J Am Vet Med Assoc. 1997 May 1;210(9):1328-31.
An 8-year-old Thoroughbred gelding was admitted for evaluation of chronic lameness of the left scapulohumeral joint of 3 months' duration. Radiography revealed a radiolucent lesion with the proximal portion of the humerus in the area of the metaphysis. Scintigraphy confirmed radiographic findings, with an increased uptake of technetium Tc 99m medronate in the proximal portion of the left humerus. A preliminary diagnosis of humeral fracture was made. Two weeks later, the horse was readmitted for clinical signs of respiratory distress. Radiographic and ultrasonographic evaluation revealed masses within the thoracic and abdominal cavities. The diagnosis was changed to neoplasm with multiple metastases. Because of the unfavorable prognosis, the horse was euthanatized. Necropsy findings confirmed an aggressive neoplasm. Special histochemical stains, immunohistochemistry, and electron microscopy were required to characterize the neoplasm as an anaplastic fibrosarcoma. Findings in this horse illustrate the importance of considering neoplasia, resulting in bone lesions, as a possible cause of chronic lameness in horses.
一匹8岁的纯种马因左肩胛肱骨关节慢性跛行3个月入院评估。放射学检查显示，在干骺端区域的肱骨近端有一个放射性透亮病变。闪烁扫描证实了放射学检查结果，左肱骨近端的锝 Tc 99m 亚甲基二膦酸盐摄取增加。初步诊断为肱骨骨折。两周后，这匹马因呼吸窘迫的临床症状再次入院。放射学和超声检查评估显示胸腔和腹腔内有肿块。诊断改为伴有多处转移的肿瘤。由于预后不良，这匹马被实施安乐死。尸检结果证实为侵袭性肿瘤。需要特殊的组织化学染色、免疫组织化学和电子显微镜检查才能将该肿瘤定性为间变性纤维肉瘤。这匹马的病例结果说明了将导致骨病变的肿瘤形成视为马慢性跛行可能原因的重要性。
