Lee S, Izumiya N
Int J Pept Protein Res. 1977;10(3):206-18.
Synthesis of a cyclohexadepsipeptide corresponding to the sequence of protodestruxin from linear hexapeptides was attempted through five different routes in a conventional method, and three routes afforded the same cyclopeptide. Biological and physiocochemical properties of the synthetic peptide were identical to those of natural protodestruxin. Differences in the yields of the cyclization were explained through the assumed conformations of the linear hexapeptides.
尝试通过传统方法中的五条不同路线，从线性六肽合成与原毁灭菌素序列相对应的环己缩肽，其中三条路线得到了相同的环肽。合成肽的生物学和物理化学性质与天然原毁灭菌素相同。通过线性六肽假定的构象解释了环化产率的差异。
