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1
An unique CD4+CD8+ intestinal intraepithelial lymphocyte specific for DnaK (Escherichia coli HSP70) may be selected by intestinal microflora of rats.一种独特的、对DnaK（大肠杆菌热休克蛋白70）具有特异性的CD4+CD8+肠上皮内淋巴细胞可能由大鼠的肠道微生物群选择产生。
Immunobiology. 1996;196(5):550-66. doi: 10.1016/s0171-2985(97)80071-x.
2
Age-associated increase in number of CD4+CD8+ intestinal intraepithelial lymphocytes in rats.
Eur J Immunol. 1992 Jan;22(1):159-64. doi: 10.1002/eji.1830220124.
3
Unique properties of a cytotoxic CD4+CD8+ intraepithelial T-cell line established from the mouse intestinal epithelium.从小鼠肠道上皮建立的细胞毒性CD4⁺CD8⁺上皮内T细胞系的独特性质。
Microbiol Immunol. 1994;38(3):191-9. doi: 10.1111/j.1348-0421.1994.tb01764.x.
4
Thymus ontogeny and the development of TCR alpha beta intestinal intraepithelial lymphocytes.胸腺个体发育与TCRαβ肠道上皮内淋巴细胞的发育
Cell Immunol. 1996 Jul 10;171(1):132-9. doi: 10.1006/cimm.1996.0183.
5
Phenotypic and functional heterogeneity of murine intestinal intraepithelial lymphocytes defined by cell density: implications for route of differentiation and responsiveness to proliferation induction.根据细胞密度定义的小鼠肠道上皮内淋巴细胞的表型和功能异质性：对分化途径和增殖诱导反应性的影响
Immunology. 1994 Aug;82(4):611-6.
6
Thymus-independent positive and negative selection of T cells expressing a major histocompatibility complex class I restricted transgenic T cell receptor alpha/beta in the intestinal epithelium.在肠上皮中，表达主要组织相容性复合体I类限制性转基因T细胞受体α/β的T细胞的非胸腺依赖性阳性和阴性选择。
J Exp Med. 1993 Dec 1;178(6):1947-57. doi: 10.1084/jem.178.6.1947.
7
Characterization of CD4+ CD8alphaalpha+ and CD4-CD8alphaalpha+ intestinal intraepithelial lymphocytes in rats.大鼠CD4+CD8αα+和CD4-CD8αα+肠上皮内淋巴细胞的特征分析
Int Immunol. 1999 Jan;11(1):21-8. doi: 10.1093/intimm/11.1.21.
8
Age-related changes of T cell subsets in intestinal intraepithelial lymphocytes of mice.小鼠肠道上皮内淋巴细胞中T细胞亚群的年龄相关变化。
Eur J Immunol. 1993 Jun;23(6):1409-11. doi: 10.1002/eji.1830230637.
9
Unusual phenotype of intestinal intraepithelial lymphocytes in the rat: predominance of T cell receptor alpha/beta+/CD2- cells and high expression of the RT6 alloantigen.大鼠肠道上皮内淋巴细胞的异常表型：T细胞受体α/β+/CD2-细胞占优势及RT6同种异体抗原的高表达。
Eur J Immunol. 1991 Mar;21(3):753-60. doi: 10.1002/eji.1830210331.
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Progenies of fetal thymocytes are the major source of CD4-CD8+ alpha alpha intestinal intraepithelial lymphocytes early in ontogeny.在个体发育早期，胎儿胸腺细胞的后代是CD4-CD8+αα肠上皮内淋巴细胞的主要来源。
Eur J Immunol. 1994 Aug;24(8):1785-91. doi: 10.1002/eji.1830240810.

引用本文的文献

1
The interaction of intestinal epithelial cells and intraepithelial lymphocytes in host defense.肠道上皮细胞与上皮内淋巴细胞在宿主防御中的相互作用。
Immunol Res. 1999;20(3):219-35. doi: 10.1007/BF02790405.

本文引用的文献

1
Evidence for the early recruitment of T-cell receptor gamma delta+ T cells during rat listeriosis.大鼠李斯特菌病期间T细胞受体γδ+ T细胞早期募集的证据。
Immunology. 1996 Jan;87(1):21-8.
2
T cell receptor-triggered activation of intraepithelial lymphocytes in vitro.体外T细胞受体触发上皮内淋巴细胞的激活。
Int Immunol. 1993 Feb;5(2):145-53. doi: 10.1093/intimm/5.2.145.
3
Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues.参与免疫球蛋白A应答的辅助性T细胞亚群：以破伤风类毒素和霍乱毒素作为佐剂进行口服免疫，可在黏膜相关组织中选择性诱导Th2细胞。
J Exp Med. 1993 Oct 1;178(4):1309-20. doi: 10.1084/jem.178.4.1309.
4
The Mycobacterium tuberculosis 71-kDa heat-shock protein induces proliferation and cytokine secretion by murine gut intraepithelial lymphocytes.结核分枝杆菌71-kDa热休克蛋白可诱导小鼠肠道上皮内淋巴细胞增殖并分泌细胞因子。
Eur J Immunol. 1993 Aug;23(8):2049-52. doi: 10.1002/eji.1830230852.
5
Different use of T cell receptor transducing modules in two populations of gut intraepithelial lymphocytes are related to distinct pathways of T cell differentiation.肠道上皮内淋巴细胞的两个亚群中T细胞受体转导模块的不同使用与T细胞分化的不同途径相关。
J Exp Med. 1994 Aug 1;180(2):673-9. doi: 10.1084/jem.180.2.673.
6
Selection of peripheral and intestinal T lymphocytes lacking CD3 zeta.缺乏CD3ζ的外周和肠道T淋巴细胞的选择。
Int Immunol. 1995 Feb;7(2):287-93. doi: 10.1093/intimm/7.2.287.
7
Age-associated changes in the proliferative response of rat intestinal intraepithelial leukocytes to bacterial antigens.
Gastroenterology. 1995 Sep;109(3):748-54. doi: 10.1016/0016-5085(95)90381-x.
8
Intraepithelial lymphocytes modulate Ia expression by intestinal epithelial cells.上皮内淋巴细胞调节肠上皮细胞Ia抗原的表达。
J Immunol. 1984 May;132(5):2244-52.
9
Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice.抗原致敏小鼠肠道黏膜中细胞毒性效应细胞的非特异性募集。
J Exp Med. 1984 Dec 1;160(6):1931-6. doi: 10.1084/jem.160.6.1931.
10
An intermediate cell in thymocyte differentiation that expresses CD8 but not CD4 antigen.胸腺细胞分化过程中的一种中间细胞，表达CD8但不表达CD4抗原。
J Exp Med. 1987 Nov 1;166(5):1603-8. doi: 10.1084/jem.166.5.1603.

一种独特的、对DnaK（大肠杆菌热休克蛋白70）具有特异性的CD4+CD8+肠上皮内淋巴细胞可能由大鼠的肠道微生物群选择产生。

An unique CD4+CD8+ intestinal intraepithelial lymphocyte specific for DnaK (Escherichia coli HSP70) may be selected by intestinal microflora of rats.

作者信息

Kimura Y, Sakai T, Takeuchi M, Matsumoto Y, Watanabe K, Yuuki M, Takada T, Yoshikai Y

机构信息

Laboratory of Host Defense and Germfree Life, Nagoya University School of Medicine, Japan.

出版信息

Immunobiology. 1996;196(5):550-66. doi: 10.1016/s0171-2985(97)80071-x.

DOI:10.1016/s0171-2985(97)80071-x
PMID:9145332
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7134423/
Abstract

We have previously shown an age-associated increase in unique CD4+CD8+ intestinal intraepithelial lymphocytes (i-IEL) in rats. To elucidate the potential causes of the increase in CD4+CD8+ i-IEL with age, we analyzed the specificity of the CD4+CD8+ i-IEL and influence of intestinal microflora on the increase in this subset in aged rats. The purified CD4+CD8+ i-IEL proliferated in response to DnaK [Escherichia coli (E. coli) HSP70] in the presence of mitomycin-c (MMC)-treated syngeneic spleen cells. The proportion of CD4+CD8+ T cells in whole i-IEL were significantly increased in aged rats fed commercial (CL-2) diet but not in those fed home-made (purified) diet under conventional condition. No CD4+CD8+ i-IEL were detected in aged rats under germfree condition, irrespective of diet feeding. A larger number of Enterobacteriaceae, especially E. coli, were detected in the intestinal contents and feces from aged rats with CD4+CD8+ i-IEL compared with those from aged rats fed without CD4+CD8+ i-IEL. The unique CD4+CD8+ i-IEL population specific for E. coli HSP may be associated with long term exposure to intestinal E. coli in aged rats.

摘要

我们之前已经表明，大鼠体内独特的CD4+CD8+肠道上皮内淋巴细胞（i-IEL）数量会随着年龄增长而增加。为了阐明CD4+CD8+ i-IEL数量随年龄增长而增加的潜在原因，我们分析了CD4+CD8+ i-IEL的特异性以及肠道微生物群对老年大鼠中该亚群增加的影响。在丝裂霉素-C（MMC）处理的同基因脾细胞存在的情况下，纯化的CD4+CD8+ i-IEL对DnaK[大肠杆菌（E. coli）HSP70]有增殖反应。在常规条件下，喂食商业（CL-2）饲料的老年大鼠全i-IEL中CD4+CD8+ T细胞的比例显著增加，但喂食自制（纯化）饲料的大鼠则没有。在无菌条件下，无论喂食何种饲料，老年大鼠中均未检测到CD4+CD8+ i-IEL。与未检测到CD4+CD8+ i-IEL的老年大鼠相比，在检测到CD4+CD8+ i-IEL的老年大鼠的肠道内容物和粪便中检测到大量肠杆菌科细菌，尤其是大肠杆菌。对大肠杆菌HSP具有特异性的独特CD4+CD8+ i-IEL群体可能与老年大鼠长期接触肠道大肠杆菌有关。