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1
Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice.抗原致敏小鼠肠道黏膜中细胞毒性效应细胞的非特异性募集。
J Exp Med. 1984 Dec 1;160(6):1931-6. doi: 10.1084/jem.160.6.1931.
2
Detection and characterization of cytotoxic T lymphocyte precursors in the murine intestinal intraepithelial leukocyte population.小鼠肠道上皮内白细胞群体中细胞毒性T淋巴细胞前体的检测与鉴定
J Immunol. 1986 Mar 15;136(6):2121-6.
3
Ontogeny of the Thy-1-, Lyt-2+ murine intestinal intraepithelial lymphocyte. Characterization of a unique population of thymus-independent cytotoxic effector cells in the intestinal mucosa.Thy-1、Lyt-2 + 小鼠肠道上皮内淋巴细胞的个体发生。肠道黏膜中一类不依赖胸腺的独特细胞毒性效应细胞群体的特征。
J Exp Med. 1986 Jul 1;164(1):309-14. doi: 10.1084/jem.164.1.309.
4
Intestinal intraepithelial lymphocytes respond to systemic lymphocytic choriomeningitis virus infection.肠道上皮内淋巴细胞对系统性淋巴细胞性脉络丛脑膜炎病毒感染有反应。
Cell Immunol. 1996 Feb 1;167(2):161-9. doi: 10.1006/cimm.1996.0023.
5
Analysis of the effector functions of different populations of mucosal lymphocytes.黏膜淋巴细胞不同群体的效应功能分析。
Ann N Y Acad Sci. 1983 Jun 30;409:307-20. doi: 10.1111/j.1749-6632.1983.tb26879.x.
6
A murine cytotoxic T lymphocyte clone from the intestinal mucosa that is antigen specific for proliferation and displays broadly reactive inducible cytotoxic activity.
J Immunol. 1985 Dec;135(6):3697-703.
7
Developmental relationship between cytotoxic alpha/beta T cell receptor-positive intraepithelial lymphocytes and Peyer's patch lymphocytes.细胞毒性α/βT细胞受体阳性上皮内淋巴细胞与派尔集合淋巴结淋巴细胞之间的发育关系。
Eur J Immunol. 1993 Jun;23(6):1333-9. doi: 10.1002/eji.1830230622.
8
Spontaneous in vitro evolution of lytic specificity of cytotoxic T lymphocyte clones isolated from murine intestinal epithelium.从小鼠肠道上皮分离的细胞毒性T淋巴细胞克隆裂解特异性的自发体外进化。
J Immunol. 1987 Jan 1;138(1):58-62.
9
Rapid killing of murine lymph node T blasts by intestinal intraepithelial lymphocytes in vitro.肠道上皮内淋巴细胞在体外对小鼠淋巴结T母细胞的快速杀伤作用。
Eur J Immunol. 1996 Mar;26(3):653-8. doi: 10.1002/eji.1830260322.
10
Intraepithelial leukocytes contain a unique subpopulation of NK-like cytotoxic cells active in the defense of gut epithelium to enteric murine coronavirus.上皮内白细胞包含一类独特的自然杀伤样细胞亚群，其在肠道上皮抵御鼠肠道冠状病毒方面具有活性。
J Immunol. 1986 Mar 1;136(5):1548-53.

引用本文的文献

1
T-cell activation in the curious world of the intestinal intraepithelial lymphocyte.肠道上皮内淋巴细胞奇妙世界中的T细胞活化
Immunol Res. 2004;30(3):327-37. doi: 10.1385/IR:30:3:327.
2
Ingestion of sugar beet fiber enhances irradiation-induced aberrant crypt foci in the rat colon under an apoptosis-suppressed condition.在细胞凋亡受到抑制的情况下，摄入甜菜纤维会增加大鼠结肠中辐射诱导的异常隐窝病灶。
Carcinogenesis. 1999 Jun;20(6):1005-9. doi: 10.1093/carcin/20.6.1005.
3
An unique CD4+CD8+ intestinal intraepithelial lymphocyte specific for DnaK (Escherichia coli HSP70) may be selected by intestinal microflora of rats.一种独特的、对DnaK（大肠杆菌热休克蛋白70）具有特异性的CD4+CD8+肠上皮内淋巴细胞可能由大鼠的肠道微生物群选择产生。
Immunobiology. 1996;196(5):550-66. doi: 10.1016/s0171-2985(97)80071-x.
4
Accumulation of donor-specific cytotoxic T cells in intestinal lymphoid tissues following intestinal transplantation.肠道移植后供体特异性细胞毒性T细胞在肠道淋巴组织中的积聚。
J Clin Immunol. 1995 Sep;15(5):258-65. doi: 10.1007/BF01540883.
5
Modulation of intestinal and systemic immune responses to a fed protein antigen, in mice.小鼠对摄入蛋白质抗原的肠道和全身免疫反应的调节
Gut. 1986 Jul;27(7):829-37. doi: 10.1136/gut.27.7.829.
6
Functional characteristics of intraepithelial lymphocytes from mouse small intestine. III. Inability of intraepithelial lymphocytes to induce a systemic graft-versus-host reaction is because of failure to migrate in vivo.小鼠小肠上皮内淋巴细胞的功能特性。III. 上皮内淋巴细胞无法诱导全身性移植物抗宿主反应是由于其在体内无法迁移。
Gut. 1987 Oct;28(10):1267-74. doi: 10.1136/gut.28.10.1267.
7
Effect of aging on immunological memory in gastrointestinal tract induced by sheep red blood cells in mice.
Gastroenterol Jpn. 1988 Feb;23(1):13-7. doi: 10.1007/BF02918850.
8
Lysis of colonic epithelial cells by allogeneic mononuclear and lymphokine activated killer cells derived from peripheral blood and intestinal mucosa: evidence against a pathogenic role in inflammatory bowel disease.来自外周血和肠黏膜的同种异体单核细胞及淋巴因子激活的杀伤细胞对结肠上皮细胞的溶解作用：反对其在炎症性肠病中致病作用的证据
Gut. 1988 Aug;29(8):1076-84. doi: 10.1136/gut.29.8.1076.
9
Spontaneous expression of the interleukin 2 receptor gene and presence of functional interleukin 2 receptors on T lymphocytes in the blood of individuals with active pulmonary sarcoidosis.活动性肺结节病患者血液中T淋巴细胞白细胞介素2受体基因的自发表达及功能性白细胞介素2受体的存在。
J Clin Invest. 1988 Sep;82(3):775-81. doi: 10.1172/JCI113678.
10
Functional characteristics of intraepithelial lymphocytes from mouse small intestine. II. In vivo and in vitro responses of intraepithelial lymphocytes to mitogenic and allogeneic stimuli.小鼠小肠上皮内淋巴细胞的功能特性。II. 上皮内淋巴细胞对促有丝分裂和同种异体刺激的体内和体外反应。
Immunology. 1986 Aug;58(4):627-34.

本文引用的文献

1
Natural killer activity of gut mucosal lymphoid cells in mice.小鼠肠道黏膜淋巴细胞的自然杀伤活性
Eur J Immunol. 1981 Nov;11(11):919-22. doi: 10.1002/eji.1830111112.
2
In vivo effects of anti-asialo GM1. I. Reduction of NK activity and enhancement of transplanted tumor growth in nude mice.抗去唾液酸GM1的体内效应。I. 裸鼠自然杀伤细胞活性降低及移植瘤生长增强
J Immunol. 1981 Jul;127(1):34-8.
3
Human intestinal mononuclear cells. I. Investigation of antibody-dependent, lectin-induced, and spontaneous cell-mediated cytotoxic capabilities.人肠道单核细胞。I. 抗体依赖性、凝集素诱导及自发性细胞介导细胞毒性能力的研究。
Gastroenterology. 1980 Jan;78(1):47-56.
4
Preparation and purification of lymphocytes from the epithelium and lamina propria of murine small intestine.从小鼠小肠上皮和固有层制备及纯化淋巴细胞。
Gut. 1981 Jun;22(6):481-8. doi: 10.1136/gut.22.6.481.
5
In vivo modulation of thymus-derived lymphocytes with monoclonal antibodies in mice. III. Spontaneous and natural cytotoxic effector cells.小鼠体内用单克隆抗体对胸腺衍生淋巴细胞的调节。III. 自发和天然细胞毒性效应细胞。
Immunology. 1984 Feb;51(2):377-85.
6
Functional characteristics of lymphocytes isolated from the rat large intestine. Response to T-cell mitogens and natural killer cell activity.从大鼠大肠分离的淋巴细胞的功能特性。对T细胞有丝分裂原的反应和自然杀伤细胞活性。
Gastroenterology. 1984 Mar;86(3):468-75.
7
Differentiation of NK-like cells from OKT3-, OKT11+, and OKM1+ small resting lymphocytes by culture with autologous T cell blasts and lymphokine.通过与自体T细胞母细胞和淋巴因子共培养，从OKT3 -、OKT11 +和OKM1 +小静止淋巴细胞中分化出自然杀伤样细胞。
J Immunol. 1984 Jun;132(6):2888-94.
8
Antigen-independent activation of memory cytotoxic T cells by interleukin 2.白细胞介素2对记忆性细胞毒性T细胞的抗原非依赖性激活。
J Immunol. 1984 Apr;132(4):1845-50.
9
Assignment of human natural killer (NK)-like cells to the T cell lineage. Single allospecific T cell clones lyse specific or NK-sensitive target cells via distinct recognition structures.将人类自然杀伤（NK）样细胞归为T细胞谱系。单个同种异体特异性T细胞克隆通过不同的识别结构裂解特异性或NK敏感靶细胞。
Eur J Immunol. 1984 Feb;14(2):121-5. doi: 10.1002/eji.1830140204.
10
Loss of specificity in cytolytic T lymphocyte clones obtained by limit dilution culture of Ly-2+ T cells.通过对Ly-2⁺ T细胞进行有限稀释培养获得的细胞毒性T淋巴细胞克隆中特异性丧失。
J Immunol. 1984 Feb;132(2):584-93.

抗原致敏小鼠肠道黏膜中细胞毒性效应细胞的非特异性募集。

Nonspecific recruitment of cytotoxic effector cells in the intestinal mucosa of antigen-primed mice.

作者信息

Klein J R, Kagnoff M F

出版信息

J Exp Med. 1984 Dec 1;160(6):1931-6. doi: 10.1084/jem.160.6.1931.

DOI:10.1084/jem.160.6.1931
PMID:6334717
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2187520/
Abstract

We have examined cytotoxic responses of lymphocytes derived from the gut epithelium of mice primed systemically and enterically with alloantigens. Both gut intraepithelial (IEL) and splenic lymphocytes from alloantigen-primed mice were found to contain antigen-specific cytotoxic T cell activity. However, after priming, gut IEL also developed high levels of natural killer and spontaneous cytotoxic cell activities. We suggest that this nonspecific activation of additional cytotoxic effector populations during an antigen-specific response is an important host immune defense within the intestinal mucosa.

摘要

我们检测了经全身和肠道用同种异体抗原致敏的小鼠肠道上皮来源淋巴细胞的细胞毒性反应。发现来自同种异体抗原致敏小鼠的肠道上皮内（IEL）淋巴细胞和脾淋巴细胞均含有抗原特异性细胞毒性T细胞活性。然而，致敏后，肠道IEL还产生了高水平的自然杀伤细胞和自发细胞毒性细胞活性。我们认为，在抗原特异性反应过程中这种额外细胞毒性效应细胞群体的非特异性激活是肠道黏膜内重要的宿主免疫防御机制。