Smalley D L, Levine J J, Shanklin D R, Hall M F, Stevens M V
Baptist Memorial Health Care System, University of Tenessee, Memphis, USA.
Immunobiology. 1996;196(5):567-74. doi: 10.1016/s0171-2985(97)80072-1.
The current study evaluated immune response to silicon dioxide in children born to women with silicone breast implants. In part one of the study, the T lymphocytes of 21 of 24 such children were significantly stimulated by silicon dioxide (silica). Part two consisted of eleven children, four born preimplantation and seven born postimplantation. None of the preimplant offspring showed T cell responses to silica; five of the seven postimplant children were positive for T cell memory for silica. Part three was a blinded study based on statistically significant differences in T cell stimulation with silicon dioxide between postimplant children and controls. These findings indicate a common immune reaction, that of T cell memory, occurs in mothers and their children born after exposure to silicone mammary implants placed prior to pregnancy. Since not all such children were breast fed the result favors transplacental passage of immunogens such as silicone oligomers or through maternofetal cellular traffic.
本研究评估了接受硅胶乳房植入术的女性所生子女对二氧化硅的免疫反应。在研究的第一部分，24名此类儿童中有21名的T淋巴细胞受到二氧化硅（硅石）的显著刺激。第二部分包括11名儿童，4名在植入术前出生，7名在植入术后出生。术前出生的后代均未表现出对二氧化硅的T细胞反应；7名植入术后儿童中有5名对二氧化硅的T细胞记忆呈阳性。第三部分是一项盲法研究，基于植入术后儿童与对照组之间在二氧化硅刺激T细胞方面的统计学显著差异。这些发现表明，在母亲及其妊娠前植入硅胶乳房植入物后出生的子女中会发生一种常见的免疫反应，即T细胞记忆。由于并非所有此类儿童都进行母乳喂养，结果支持免疫原如硅氧烷低聚物通过胎盘传递或通过母婴细胞转运。
