Shanklin D R, Smalley D L
Department of Pathology, University of Tennessee, Memphis 38163, USA.
Immunol Res. 1998;18(3):125-73. doi: 10.1007/BF02788777.
Recent evidence confirms the fundamental involvement of the human immune system in the reaction to implantation of silicone-based medical devices. An as yet-to-be particularized epitope of many complex substances sharing siloxane structures is presented through the MHC-II apparatus with development and retention of T cell memory. This memory can be tested for in practical terms using one or more forms of silica, which links the immuno-histopathology and autoimmune attributes of "silicosis" with those of "siliconosis." The lesions of siliconosis are typical of those for persistent antigens and delayed, cell mediated hypersensitivity. The basic descriptive pathology of the reaction to silicone has been known since soon after introduction of silicones in medical procedures, with the exception of some details related to the more recent discoveries on the role of cytokines in the immunopathic process. The clinical consequences of siliconosis are common and can be severe in some individuals implanted with silicone devices.
最近的证据证实，人类免疫系统在对硅基医疗设备植入的反应中起着根本性作用。许多具有硅氧烷结构的复杂物质的一个尚未明确的表位通过MHC-II机制呈递，并伴随着T细胞记忆的形成和保留。实际上，可以使用一种或多种形式的二氧化硅来检测这种记忆，它将“矽肺”的免疫组织病理学和自身免疫属性与“硅肺病”的相关属性联系起来。硅肺病的病变是持续性抗原和迟发型细胞介导超敏反应的典型病变。自从硅酮被引入医疗程序后不久，人们就已经知道了对硅酮反应的基本描述性病理学，只是与细胞因子在免疫病理过程中的作用相关的一些最新发现的细节除外。硅肺病的临床后果很常见，在一些植入硅酮设备的个体中可能很严重。
