Uribe-Esquivel M, Moran S, Poo J L, Muñoz R M
Departamento de Gastroenterología, Instituto Nacional de la Nutrición Salvador Zubirán, Tlalpan, México, D.F, México.
Scand J Gastroenterol Suppl. 1997;222:49-52. doi: 10.1080/00365521.1997.11720718.
Lactose intolerance occurs in the majority of human groups, excluding people from Northern Europe. Because its effect is similar to that of lactulose, lactose seems to be an alternative treatment for patients with portal-systemic encephalopathy (PSE) and lactase deficiency. The mechanism of action of lactose is similar to that of lactulose. In vivo, lactose improves PSE parameters and causes acidic diarrhea. We performed in vitro studies in a fecal incubation system to investigate the biochemical and bacteriological effects induced by different substances customarily used for the treatment of patients with PSE (lactose, lactulose and Neomycin). In vitro experiments showed that lactose and lactulose decreased aerobic flora counts and reduced the pH of fecal incubation. Both disaccharides reduced the ammonia concentration in the incubation system.
乳糖不耐受在大多数人类群体中都有发生，北欧人群除外。由于乳糖的作用与乳果糖相似，它似乎是门静脉-体循环性脑病（PSE）和乳糖酶缺乏患者的一种替代治疗方法。乳糖的作用机制与乳果糖相似。在体内，乳糖可改善PSE参数并引起酸性腹泻。我们在粪便培养系统中进行了体外研究，以调查通常用于治疗PSE患者的不同物质（乳糖、乳果糖和新霉素）所诱导的生化和细菌学效应。体外实验表明，乳糖和乳果糖可降低需氧菌群数量并降低粪便培养的pH值。两种二糖都降低了培养系统中的氨浓度。
