Savitz S I
Mt Sinai J Med. 1997 May;64(3):187-8.
Leonard I. Malis introduced important changes in the antimicrobial regimen for neurosurgical procedures at The Mount Sinai Hospital. Among Dr. Malis' innovations, intraoperative administration of a single dose each of vancomycin and gentamicin or tobramicin and constant irrigation of the surgical site with a bactericidal antibiotic (streptomycin) led to the elimination of primary wound infections during a 20-year period. In a study to locate potential sources of microbial contamination in his operating room, this combination of parenteral antibiotics was justified, because 36% of patients were at risk for exposure to methicillin-resistant Staphylococcus aureus and Gram-negative bacteria. Streptomycin as a topical agent was found to be highly efficacious in preventing intraoperative growth of potential pathogens cultured from the surgical wound and the operating room environment.
伦纳德·I·马利斯（Leonard I. Malis）在西奈山医院对神经外科手术的抗菌方案进行了重要变革。在马利斯医生的诸多创新举措中，术中单次给予万古霉素和庆大霉素或妥布霉素各一剂，并使用杀菌抗生素（链霉素）持续冲洗手术部位，使得在20年期间原发性伤口感染得以消除。在一项旨在确定其手术室潜在微生物污染源的研究中，这种肠外抗生素联合使用是合理的，因为36%的患者有接触耐甲氧西林金黄色葡萄球菌和革兰氏阴性菌的风险。链霉素作为局部用药，在预防从手术伤口和手术室环境中培养出的潜在病原体术中生长方面被发现具有高效性。
