Ruilope L M
Unidad de Hipertensión, Hospital 12 de Octubre, Madrid, Spain.
Curr Opin Nephrol Hypertens. 1997 Mar;6(2):152-6. doi: 10.1097/00041552-199703000-00008.
Renal vascular damage caused by arterial hypertension participates in alterations of the systemic vascular function and structure. Nephrosclerosis seems to run in parallel with the systemic atherosclerosis that accounts for the increased cardiovascular morbidity and mortality seen in hypertensive patients. Parameters indicating the existence of an alteration in renal function (increased serum creatinine, proteinuria and microalbuminuria) are independent predictors for an increased cardiovascular morbidity and mortality. Hence, parameters of renal function must be considered in any stratification of cardiovascular risk in hypertensive patients.
动脉高血压引起的肾血管损伤参与了全身血管功能和结构的改变。肾硬化似乎与全身动脉粥样硬化同时发生,这也是高血压患者心血管发病率和死亡率增加的原因。表明肾功能改变的参数(血清肌酐升高、蛋白尿和微量白蛋白尿)是心血管发病率和死亡率增加的独立预测因素。因此,在对高血压患者进行心血管风险分层时,必须考虑肾功能参数。