Ruilope L M
Hypertension Unit, Hospital 12 de Octubre, Madrid, Spain.
J Cardiovasc Pharmacol. 1999;33 Suppl 1:S7-10; discussion S41-3. doi: 10.1097/00005344-199900001-00002.
Renal vascular damage caused by arterial hypertension brings about changes in the systemic vascular function and structure. Nephrosclerosis appears to run in parallel with systemic atherosclerosis, accounting for the increased cardiovascular morbidity and mortality in hypertensive patients. Parameters indicating a change in renal function (increased serum creatinine concentration, proteinuria, and microalbuminuria) are independent predictors of increased cardiovascular morbidity and mortality and must therefore be considered in the classification of cardiovascular risk in hypertensive patients.
动脉高血压引起的肾血管损伤会导致全身血管功能和结构的改变。肾硬化似乎与全身动脉粥样硬化同时存在，这也是高血压患者心血管发病率和死亡率增加的原因。表明肾功能变化的参数（血清肌酐浓度升高、蛋白尿和微量白蛋白尿）是心血管发病率和死亡率增加的独立预测因素，因此在高血压患者心血管风险分类中必须予以考虑。
