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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Velasco A, Alamo C, Hervás J, Carvajal A

Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Valladolid, Spain.

Gen Pharmacol. 1997 Apr;28(4):509-12. doi: 10.1016/s0306-3623(96)00274-1.

Fluoxetine and fluvoxamine reinforced the response to norepinephrine of isolated rat vas deferens incubated in Krebs-Henseleit solution. 2. This reinforcement disappeared when cocaine, 17 beta-estradiol, and propranolol were added to the incubation medium. 3. Fluoxetine and fluvoxamine did not have antimuscarinic effect, but they did have antihistaminic effect, and at high concentrations they inhibited the contraction induced by potassium ion on the isolated rat uterus preparation (IC50 3.99 x 10(-6) and 1.82 x 10(-5) M, respectively).

Velasco A, Alamo C, Hervás J, Carvajal A

Department of Pharmacology and Therapeutics, Faculty of Medicine, University of Valladolid, Spain.

Gen Pharmacol. 1997 Apr;28(4):509-12. doi: 10.1016/s0306-3623(96)00274-1.

Fluoxetine and fluvoxamine reinforced the response to norepinephrine of isolated rat vas deferens incubated in Krebs-Henseleit solution. 2. This reinforcement disappeared when cocaine, 17 beta-estradiol, and propranolol were added to the incubation medium. 3. Fluoxetine and fluvoxamine did not have antimuscarinic effect, but they did have antihistaminic effect, and at high concentrations they inhibited the contraction induced by potassium ion on the isolated rat uterus preparation (IC50 3.99 x 10(-6) and 1.82 x 10(-5) M, respectively).