Brodaty H, Luscombe G
Academic Department of Psychogeriatrics, Prince Henry Hospital, Sydney, New South Wales, Australia.
Int Psychogeriatr. 1996 Winter;8(4):609-22. doi: 10.1017/s104161029600292x.
The prevalence of depression in persons with dementia is controversial. Among 288 outpatients with dementia, a prevalence of 7.4% was found according to the Hamilton Rating Scale for Depression (HRSD), 8.0% using the Geriatric Depression Scale (GDS), and 6.3% according to DSM-IV criteria. Rates and levels of depression tended to be higher in vascular than in Alzheimer's dementia according to the rating scales, but not according to the DSM-IV criteria. Greater cognitive impairment was associated with higher HRSD (but not GDS) scores. Cases of clinical depression did not persist over 12 months' follow-up. These results suggest that clinically significant depression in dementia is less common than previously reported and tends to remit.
痴呆症患者中抑郁症的患病率存在争议。在288名痴呆症门诊患者中，根据汉密尔顿抑郁量表（HRSD）得出的患病率为7.4%，使用老年抑郁量表（GDS）得出的患病率为8.0%，根据《精神疾病诊断与统计手册》第四版（DSM-IV）标准得出的患病率为6.3%。根据这些评定量表，血管性痴呆患者的抑郁发生率和程度往往高于阿尔茨海默病痴呆患者，但根据DSM-IV标准并非如此。更严重的认知障碍与更高的HRSD（而非GDS）评分相关。临床抑郁症病例在12个月的随访中并未持续存在。这些结果表明，痴呆症中具有临床意义的抑郁症比先前报道的更为少见，且往往会缓解。
