Rosen J, Zubenko G S
Geriatric Health Services, University of Pittsburgh School of Medicine, PA 15213.
Biol Psychiatry. 1991 Feb 1;29(3):224-32. doi: 10.1016/0006-3223(91)91284-x.
Prospective psychiatric evaluations were performed as part of a longitudinal study of 32 demented patients who met criteria for the histopathological diagnosis of Alzheimer's disease at the time of death. Psychosis and major depressive disorder emerged in 15 (47%) and 7 (22%) patients, respectively, none of whom had a history of either behavioral disorder prior to the onset of dementia. The prevalence of psychosis increased with increasing dementia severity, was associated with more rapid cognitive decline, and once present was often persistent. In this regard, the emergence of psychosis in the context of Alzheimer's disease appears to be a poor prognostic sign. In contrast to its relationship to cognitive impairment, psychosis was not associated with an increased mortality rate.
作为一项对32名痴呆患者进行的纵向研究的一部分，在患者死亡时进行了前瞻性精神病学评估，这些患者符合阿尔茨海默病组织病理学诊断标准。分别有15名（47%）和7名（22%）患者出现了精神病和重度抑郁症，他们在痴呆症发作之前均无任何一种行为障碍的病史。精神病的患病率随着痴呆症严重程度的增加而上升，与认知能力下降更快有关，且一旦出现往往持续存在。在这方面，阿尔茨海默病患者出现精神病似乎是一个预后不良的迹象。与它和认知障碍的关系不同，精神病与死亡率增加无关。
