Jackson A C, Butler J P, Millet E J, Hoppin F G, Dawson S V
J Appl Physiol Respir Environ Exerc Physiol. 1977 Sep;43(3):523-36. doi: 10.1152/jappl.1977.43.3.523.
Serial distribution of airway properties determines in part the response of the lung to high frequency oscillations. We measured the response of excised dog lungs and lobes between 156 and 10,000 Hz and determined the area-distance function of the acoustically equivalent structure having rigid walls, regular branching, and negligible internal losses. The utility of this techique was tested by determining the effects of air trapping, removal of pleura from a dried lung, central airway smooth muscle tone. A strong correlation was found between relative changes in equivalent acoustic area and relative area changes measured radiographically in individual airways at corresponding distances. We conclude that despite departures of the properties of the real lung from the characteristics of the acoustically equivalent structure, changes in the area-distance function computed by this technique provide reasonable estimates of the magnitude and serial distribution of actual changes in airway cross-sectional area.
气道特性的序列分布部分决定了肺对高频振荡的反应。我们测量了切除的犬肺和肺叶在156至10000赫兹之间的反应，并确定了具有刚性壁、规则分支且内部损耗可忽略不计的声学等效结构的面积-距离函数。通过确定气体潴留、从干燥肺脏去除胸膜、中央气道平滑肌张力的影响来测试该技术的实用性。在等效声学面积的相对变化与在相应距离处的单个气道中通过射线照相测量的相对面积变化之间发现了很强的相关性。我们得出结论，尽管真实肺脏的特性与声学等效结构的特征存在差异，但通过该技术计算的面积-距离函数的变化为气道横截面积实际变化的大小和序列分布提供了合理的估计。
