独脚金的抗雄激素作用。
Antiandrogenic effect of Striga orobanchioides.
作者信息
Hiremath S P, Badami S, Swamy H K, Patil S B, Londonkar R L
机构信息
Department of Chemistry, Gulbarga University, India.
出版信息
J Ethnopharmacol. 1997 Mar;56(1):55-60. doi: 10.1016/s0378-8741(96)01505-x.
The ethanolic extract of the whole plant of Striga orobanchioides given for 7 days to immature male rats at a dose level of 200 mg/kg body weight caused a significant decrease in the weight of the testes, epididymis, seminal vesicles and the ventral prostate. It also produced degenerative changes of Leydig cells, their nucleus, the seminiferous tubules and a significant decrease in the number of spermatocytes and spermatids. The seminiferous tubules of the treated rats are shrunken and compactly arranged. The antiandrogenic or antispermatogenic effect of the extract is discussed.
将 Orobanchioides 列当属全株乙醇提取物以200毫克/千克体重的剂量水平给予未成熟雄性大鼠7天，会导致睾丸、附睾、精囊和腹侧前列腺重量显著减轻。它还会引起睾丸间质细胞、其细胞核、生精小管的退行性变化，以及精母细胞和精子细胞数量的显著减少。经处理的大鼠的生精小管萎缩且排列紧密。讨论了该提取物的抗雄激素或抗生精作用。
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