Mayer H, von der Ohe N
Kinik und Poliklinik fur Augenheilkunde, Medizinische Hochschule Hannover, Deutschland.
Ophthalmologica. 1996;210(2):101-3. doi: 10.1159/000310682.
In a two-period crossover study, 20 subjects without an ocular disease received single doses of either a novel timolol hydrogel (T-Gel 0.1%) or aqueous timolol 0.5% in one eye and placebo in the fellow eye. Diurnal variation curves of intraocular pressure of both eyes were obtained for a 24-hour period. Peak effects up to -30% of the baseline were observed. A statistically significant residual effect was still detectable 24 h after application. The timolol gel had the same efficacy in lowering intraocular pressure as the commercially available aqueous timolol solution with a five times higher strength. Equivalence of treatment effects was statistically proved.
在一项两阶段交叉研究中，20名无眼部疾病的受试者单眼接受新型噻吗洛尔水凝胶（0.1%噻吗洛尔凝胶）或0.5%噻吗洛尔水溶液，另一只眼接受安慰剂。在24小时内获取双眼眼压的昼夜变化曲线。观察到峰值效应高达基线的-30%。用药后24小时仍可检测到具有统计学意义的残留效应。噻吗洛尔凝胶降低眼压的效果与市售强度高五倍的噻吗洛尔水溶液相同。治疗效果的等效性得到了统计学证明。
