一名老挝Vogt-小柳-原田病患者的临床与免疫遗传学调查

Clinical and immunogenetic investigation of a Laotian patient with Vogt-Koyanagi-Harada's disease.

作者信息

Shindo Y, Inoko H, Nakamura S, Onoe K, Inoue T, Ohno S

机构信息

Department of Ophthalmology, Yokohama City University School of Medicine, Japan.

出版信息

Ophthalmologica. 1996;210(2):112-4. doi: 10.1159/000310685.

DOI:10.1159/000310685

PMID:9148256

Abstract

Vogt-Koyanagi-Harada's (VKH) disease has been known to be associated with HLA class II antigen, HLA-DR4 and -DR53. Recent recombinant DNA technical advances have allowed us to investigate the genetic polymorphism of HLA antigens at the molecular level. By use of the polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP) technique we have found that VKH disease is closely associated with HLA-DRB104 (DRB10405/ DRB10410) and DQB104 (DQB10401/DQB10402) in the Japanese. Here, we will describe a typical case of a Laotian patient with VKH disease and the results of HLA typing: the patient showed a conservation of one of the major haplotypes observed in Japanese VKH patients, DRB10405-DQB10402.

摘要

伏格特-小柳-原田病（VKH病）已知与人类白细胞抗原（HLA）II类抗原、HLA-DR4和-DR53相关。最近，重组DNA技术的进展使我们能够在分子水平上研究HLA抗原的基因多态性。通过使用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术，我们发现在日本人中，VKH病与HLA-DRB104（DRB10405/DRB10410）和DQB104（DQB10401/DQB10402）密切相关。在此，我们将描述一名老挝VKH病患者的典型病例以及HLA分型结果：该患者显示出在日本VKH病患者中观察到的主要单倍型之一DRB10405-DQB10402的保守性。